Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory Reproductive Center, 550 Peachtree Street, Suite 1800, Atlanta, GA, 30308, USA.
Institute for Clinical and Translational Science, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
J Assist Reprod Genet. 2021 May;38(5):1171-1175. doi: 10.1007/s10815-021-02178-1. Epub 2021 Apr 1.
To characterize national oocyte donation practice patterns from the perspective of individual donors rather than of recipients.
Retrospective cohort including all donor oocyte retrievals and transfers reported to SARTCORS in 2016 and 2017 in the USA. Primary outcomes include characteristics of oocyte donors and of donor oocyte cycles. Secondary outcomes include overall pregnancy rates, elective single embryo transfer (eSET) rates, and perinatal outcomes among donor oocyte recipient transfers.
During the study period, 49,193 donor oocyte retrievals were performed, of which the largest proportion were in the Western US. For all reported retrievals, there were 17,099 unique donors, each of whom underwent an average of 2.4 retrievals (range 1-22). Average donor age was 26.3 years (range 18-48). On average, 24.6 oocytes (SD 12.4) were retrieved each cycle, ranging from 0 to 102. Among 37,657 donor oocyte recipient transfers, 20,159 (53.5%) involved eSET, and 17,725 (47.1%) resulted in live birth. Miscarriage rates were 17.5%, and good perinatal outcome (GPO), defined as full-term normal birthweight delivery, was more likely among singleton (75.7%) than multiple (23.8%) pregnancies.
The average number of retrievals that donors underwent and oocyte yield mirrored national guidelines; however outliers, exist that may unnecessarily increase donor risk. Additionally, among resultant donor transfers, 46.5% transferred more than one embryo despite national recommendations for eSET. The significantly higher likelihood of GPO among singleton pregnancies points to the need to further increase donor recipient eSET rates.
从供体的角度而非受体的角度来描述全国范围内的卵子捐赠实践模式。
这是一项回顾性队列研究，纳入了 2016 年和 2017 年在美国 SARTCORS 报告的所有供卵取卵和移植周期。主要结局包括供卵者的特征和供卵周期的特征。次要结局包括供卵受者移植的总妊娠率、选择性单胚胎移植（eSET）率和围产期结局。
在研究期间，共进行了 49193 次供卵取卵，其中大部分发生在美国西部。对于所有报告的取卵，共有 17099 名供卵者，每位供卵者平均进行了 2.4 次取卵（范围 1-22）。平均供卵者年龄为 26.3 岁（范围 18-48）。平均每个周期取卵 24.6 个（SD 12.4），范围 0-102。在 37657 次供卵受者移植中，20159 次（53.5%）涉及 eSET，17725 次（47.1%）导致活产。流产率为 17.5%，良好围产期结局（GPO），定义为足月正常出生体重分娩，在单胎妊娠（75.7%）中比多胎妊娠（23.8%）更常见。
供体接受的取卵次数和取卵量与国家指南相符；然而，存在一些异常值，可能会不必要地增加供体的风险。此外，在供体移植中，尽管国家建议进行 eSET，但仍有 46.5%的患者移植了不止一个胚胎。单胎妊娠中 GPO 的可能性显著增加，这表明需要进一步提高供受者的 eSET 率。
