健康科学研究人员的随机单病例干预设计与分析：多功能临床试验指南
Randomized Single-Case Intervention Designs and Analyses for Health Sciences Researchers: A Versatile Clinical Trials Companion.
作者信息
Levin Joel R, Kratochwill Thomas R
机构信息
Emeritus of Educational Psychology, University of Arizona, 3850 E. Placita de Peri, Tucson, AZ, 85718, USA.
Emeritus of Educational Psychology, University of Wisconsin-Madison, S 7572 Oak Road, Merrimac, WI, 53561, USA.
出版信息
Ther Innov Regul Sci. 2021 Jul;55(4):755-764. doi: 10.1007/s43441-021-00274-z. Epub 2021 Apr 1.
AIM
An expository note introduces health sciences researchers to randomized single-case intervention designs, an adaptation of interrupted time-series methodology, and the staple of a scientifically credible small-sample research paradigm.
METHODS
Detailed examples illustrating two different randomized single-case procedures are presented to highlight the techniques' advantages relative to small-sample nonparametric procedures that are commonly applied in the medical and health sciences fields.
RESULTS
Numerous positive outcomes, based on both statistical simulation studies and actual intervention research investigations, support the applicability and value of these procedures.
CONCLUSION
Randomized single-case intervention designs are recommended for consideration by health sciences researchers.
目的
一篇说明性短文向健康科学研究人员介绍随机单病例干预设计，这是一种对中断时间序列方法的改编，也是科学可信的小样本研究范式的主要内容。
方法
给出详细示例说明两种不同的随机单病例程序，以突出这些技术相对于医学和健康科学领域常用的小样本非参数程序的优势。
结果
基于统计模拟研究和实际干预研究调查的大量积极结果，支持了这些程序的适用性和价值。
结论
建议健康科学研究人员考虑采用随机单病例干预设计。
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