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基于深度学习的明场扫描光学显微镜聚焦成像误差补偿方法。

Imaging error compensation method for through-focus scanning optical microscopy images based on deep learning.

机构信息

Key Laboratory of Precision Opto-Mechatronics, Technology of Education Ministry, School of Instrumentation and Opto-Electronic Engineering, Beihang University, Beijing, China.

School of Instrumentation and Opto-Electronic Engineering, Beihang University, Beijing, China.

出版信息

J Microsc. 2021 Aug;283(2):93-101. doi: 10.1111/jmi.13011. Epub 2021 Apr 14.

DOI:10.1111/jmi.13011
PMID:33797077
Abstract

Through-focus scanning optical microscopy (TSOM) is a model-based nanoscale metrology technique which combines conventional bright-field microscopy and the relevant numerical simulations. A TSOM image is generated after through-focus scanning and data processing. However, the mechanical vibration and optical noise introduced into the TSOM image during image generation can affect the measurement accuracy. To reduce this effect, this paper proposes a imaging error compensation method for the TSOM image based on deep learning with U-Net. Here, the simulated TSOM image is regarded as the ground truth, and the U-Net is trained using the experimental TSOM images by means of a supervised learning strategy. The experimental TSOM image is first encoded and then decoded with the U-shaped structure of the U-Net. The difference between the experimental and simulated TSOM images is minimised by iteratively updating the weights and bias factors of the network, to obtain the compensated TSOM image. The proposed method is applied for optimising the TSOM images for nanoscale linewidth estimation. The results demonstrate that the proposed method performs as expected and provides a significant enhancement in accuracy.

摘要

聚焦扫描光学显微镜(TSOM)是一种基于模型的纳米级计量技术,它结合了传统的明场显微镜和相关的数值模拟。通过聚焦扫描和数据处理后生成 TSOM 图像。然而,在图像生成过程中引入的机械振动和光学噪声会影响测量精度。为了降低这种影响,本文提出了一种基于 U-Net 的深度学习的 TSOM 图像成像误差补偿方法。在这里,模拟的 TSOM 图像被视为真实值,通过监督学习策略,使用实验 TSOM 图像对 U-Net 进行训练。实验 TSOM 图像首先由 U-Net 的 U 形结构进行编码,然后进行解码。通过迭代更新网络的权重和偏置因子,最小化实验和模拟 TSOM 图像之间的差异,从而获得补偿后的 TSOM 图像。该方法应用于优化 TSOM 图像进行纳米线宽估计。结果表明,该方法符合预期,显著提高了精度。

相似文献

1
Imaging error compensation method for through-focus scanning optical microscopy images based on deep learning.基于深度学习的明场扫描光学显微镜聚焦成像误差补偿方法。
J Microsc. 2021 Aug;283(2):93-101. doi: 10.1111/jmi.13011. Epub 2021 Apr 14.
2
A through-focus scanning optical microscopy dimensional measurement method based on deep-learning classification model.基于深度学习分类模型的逐焦扫描光学显微镜三维测量方法。
J Microsc. 2021 Aug;283(2):117-126. doi: 10.1111/jmi.13013. Epub 2021 Apr 27.
3
Motion-free TSOM using a deformable mirror.使用可变形镜的无运动颞骨光学显微镜
Opt Express. 2020 May 25;28(11):16352-16362. doi: 10.1364/OE.394939.
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Lateral movement and angular illuminating non-uniformity corrected TSOM image using Fourier transform.使用傅里叶变换进行横向移动和角向照明不均匀性校正的全内反射荧光显微镜图像
Opt Express. 2020 Mar 2;28(5):6294-6305. doi: 10.1364/OE.382748.
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Through-focus scanning optical microscopy with the Fourier modal method.基于傅里叶模态法的透焦扫描光学显微镜。
Opt Express. 2018 Apr 30;26(9):11649-11657. doi: 10.1364/OE.26.011649.
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Multiple parametric nanoscale measurements with high sensitivity based on through-focus scanning optical microscopy.基于全聚焦扫描光学显微镜的具有高灵敏度的多参数纳米级测量。
J Microsc. 2019 Jun;274(3):139-149. doi: 10.1111/jmi.12792. Epub 2019 May 3.
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Machine-learning models for analyzing TSOM images of nanostructures.用于分析纳米结构热扫描光学显微镜(TSOM)图像的机器学习模型。
Opt Express. 2019 Nov 11;27(23):33978-33998. doi: 10.1364/OE.27.033978.
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Noise analysis for through-focus scanning optical microscopy.透焦扫描光学显微镜的噪声分析
Opt Lett. 2016 Feb 15;41(4):745-8. doi: 10.1364/OL.41.000745.
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Optimizing noise for defect analysis with through-focus scanning optical microscopy.通过聚焦扫描光学显微镜优化用于缺陷分析的噪声。
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Defect height estimation via model-less TSOM under optical resolution.在光学分辨率下通过无模型热扫描光学显微镜进行缺陷高度估计。
Opt Express. 2021 Aug 16;29(17):27508-27520. doi: 10.1364/OE.433853.

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