Department of Ophthalmology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia.
Ocul Immunol Inflamm. 2022 Aug;30(6):1447-1448. doi: 10.1080/09273948.2021.1889611. Epub 2021 Apr 2.
To describe the first case of varicella zoster virus (VZV) retinitis following chimeric antigenic response (CAR) T-cell therapy.
Case review.
A 53-year-old male was treated with CAR T-cell therapy for refractory diffuse large B-cell lymphoma. Nine months after CAR T-cell therapy, he developed VZV skin infection and retinitis. The retinitis responded to systemic acyclovir therapy and intravitreal ganciclovir.
VZV retinitis can occur following CAR T-cell immunotherapy.
描述首例嵌合抗原受体（CAR）T 细胞治疗后水痘带状疱疹病毒（VZV）视网膜炎病例。
病例回顾。
一名 53 岁男性因难治性弥漫性大 B 细胞淋巴瘤接受 CAR T 细胞治疗。CAR T 细胞治疗后 9 个月，他发生 VZV 皮肤感染和视网膜炎。视网膜炎对全身阿昔洛韦治疗和玻璃体内更昔洛韦治疗有反应。
CAR T 细胞免疫治疗后可发生 VZV 视网膜炎。
