Satoh N, Abe T, Nakajima A, Sakuragi S
Department of Ophthalmology, Akita University School of Medicine, Japan.
Ocul Immunol Inflamm. 1998 Sep;6(3):185-8. doi: 10.1076/ocii.6.3.185.4040.
A case of recurrent unilateral varicella-zoster virus (VZV) retinitis is reported. The retinitis was characterized by arteriolitis and retinal necrosis with secondary chorioretinal atrophy localized in the periphery of the supratemporal quadrant of the retina. Polymerase chain reaction analysis of aqueous humor demonstrated VZV DNA in both the initial and recurrent episode. The Goldmann-Witmer coefficient for VZV IgG was elevated. The initial VZV retinitis was successfully treated with acyclovir and corticosteroids. Three years later, high-dose corticosteroids alone were used to treat idiopathic facial nerve palsy. One month after concluding corticosteroids therapy, the VZV retinitis recurred in the same eye, suggesting that administration of the high-dose corticosteroids caused VZV reactivation and induced recurrence of VZV retinitis.
报告了一例复发性单侧水痘-带状疱疹病毒（VZV）视网膜炎病例。该视网膜炎的特征为小动脉炎和视网膜坏死，并伴有继发性脉络膜视网膜萎缩，局限于视网膜颞上象限周边部。房水的聚合酶链反应分析显示，在初次发作和复发发作时均检测到VZV DNA。VZV IgG的戈德曼-维特默系数升高。初次VZV视网膜炎经阿昔洛韦和皮质类固醇成功治疗。三年后，单独使用大剂量皮质类固醇治疗特发性面神经麻痹。在结束皮质类固醇治疗一个月后，同一只眼睛再次发生VZV视网膜炎，提示大剂量皮质类固醇给药导致VZV再激活并诱发VZV视网膜炎复发。
