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Proliferating cell nuclear antigen (PCNA) overexpression in hepatocellular carcinoma predicts poor prognosis as determined by bioinformatic analysis.

作者信息

Li Dan-Dan, Zhang Jia-Wei, Zhang Rui, Xie Jie-Hong, Zhang Kuo, Lin Gui-Gao, Han Yan-Xi, Peng Rong-Xue, Han Dong-Sheng, Wang Jie, Yang Jing, Li Jin-Ming

机构信息

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China.

Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

出版信息

Chin Med J (Engl). 2020 Nov 3;134(7):848-850. doi: 10.1097/CM9.0000000000001192.

DOI:10.1097/CM9.0000000000001192
PMID:33797470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8104276/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24fe/8104276/ff1f01305a9b/cm9-134-848-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24fe/8104276/ff1f01305a9b/cm9-134-848-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24fe/8104276/ff1f01305a9b/cm9-134-848-g001.jpg

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Proliferating cell nuclear antigen (PCNA) overexpression in hepatocellular carcinoma predicts poor prognosis as determined by bioinformatic analysis.通过生物信息学分析确定，增殖细胞核抗原（PCNA）在肝细胞癌中的过表达预示着预后不良。
Chin Med J (Engl). 2020 Nov 3;134(7):848-850. doi: 10.1097/CM9.0000000000001192.
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Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma.增殖细胞核抗原表达在肝细胞癌中的预后意义
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PCNA in Pan-Cancer: A Prognostic Biomarker Unveiled Through a Data-Driven, Multidimensional Analysis of Transcriptomics, Immunity, and Functional Profiling.泛癌中的增殖细胞核抗原（PCNA）：通过转录组学、免疫和功能谱的数据驱动多维分析揭示的一种预后生物标志物
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Downregulated TRAF3IP2-AS1 promotes hepatocellular carcinoma progression through the miR-374a-5p/SEL1L1/RPL6 axis to enhance DNA damage repair.下调的TRAF3IP2-AS1通过miR-374a-5p/SEL1L1/RPL6轴促进肝细胞癌进展，以增强DNA损伤修复。
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NUB1 reduction promotes PCNA-mediated tumor growth by disturbing the PCNA polyubiquitination/NEDDylation in hepatocellular carcinoma cells.
NUB1表达降低通过干扰肝癌细胞中PCNA的多聚泛素化/类泛素化修饰促进PCNA介导的肿瘤生长。
Cell Death Dis. 2025 Mar 31;16(1):228. doi: 10.1038/s41419-025-07567-3.
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Identification and evaluation of plasma exosome RNA biomarkers for non-invasive diagnosis of hepatocellular carcinoma using RNA-seq.使用RNA测序技术鉴定和评估用于肝细胞癌无创诊断的血浆外泌体RNA生物标志物
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The Proliferating Cell Nuclear Antigen (PCNA) Transcript Variants as Potential Relapse Markers in B-Cell Acute Lymphoblastic Leukemia.增殖细胞核抗原（PCNA）转录变体作为 B 细胞急性淋巴细胞白血病潜在的复发标志物。
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