TECNALIA, Basque Research and Technology Alliance (BRTA), Área Anardi, 5, E-20730, Azpeitia, Gipuzkoa, Spain.
Ferrer, Cosmetic Development, C/Joan XXIII, 10, E-08950, Esplugues de Llobregat, Spain.
Parasitol Res. 2021 May;120(5):1883-1890. doi: 10.1007/s00436-021-07113-y. Epub 2021 Apr 2.
Head lice (Pediculus humanus capitis) are worldwide obligate human ectoparasites, with high implications in pediatrics. In Europe, first-line topical neurotoxic insecticidal therapeutic strategies are being replaced by topical physically acting agents as the first-choice treatment. Safety of the active ingredients and high efficacy in a one-time single-dose treatment with a brief treatment application time are key issues for consumer use and effective compliance. The aim of this study was to assess the in vitro efficacy of a newly developed squalane and dimethicone-based pediculicidal formula, against motile head lice and eggs after 2 and 5 min immersion in the product, as well as its skin tolerance and acceptability under dermatological and pediatric expert control in children with atopic skin. The results indicate that at both time points, 100% mortality rate of head lice crawling stages and late-stage eggs was achieved. The formula was well tolerated and suitable for children with atopic skin from 12 months of age. Showing high in vitro efficacy and good skin acceptability, this solution is presented as a new safe alternative therapy for treatment of head lice infestations.
头虱（Pediculus humanus capitis）是全球性的、专性的人体外寄生虫，在儿科领域具有重要意义。在欧洲，传统的一线局部神经毒性杀虫剂治疗策略正逐渐被局部物理作用药物取代，成为首选的治疗方法。对于消费者使用和有效依从性来说，活性成分的安全性和单次使用、短时间涂抹即可达到高效的特点至关重要。本研究旨在评估一种新开发的基于角鲨烷和二甲硅油的杀头虱配方在产品中浸泡 2 分钟和 5 分钟后对活动头虱和卵的体外疗效，以及在特应性皮炎儿童中，由皮肤科和儿科专家控制下进行的皮肤耐受性和可接受性。结果表明，在这两个时间点，100%的爬行阶段和晚期卵的死亡率都达到了。该配方耐受性良好，适用于 12 个月以上的特应性皮炎儿童。该溶液具有高体外疗效和良好的皮肤可接受性，为头虱感染的治疗提供了一种新的安全替代疗法。
