糖皮质激素对大鼠被动皮肤过敏反应及某些化学介质所致血管通透性增加的抑制作用。

Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.

作者信息

Inagaki N, Miura T, Nagai H, Koda A

机构信息

Department of Pharmacology, Gifu Pharmaceutical University, Japan.

出版信息

Jpn J Pharmacol. 1988 Feb;46(2):189-92. doi: 10.1254/jjp.46.189.

DOI:10.1254/jjp.46.189

PMID:3379829

Abstract

Effects of hydrocortisone, prednisolone and dexamethasone on IgE antibody-mediated homologous passive cutaneous anaphylaxis (PCA) and mediator-induced skin reactions were investigated. PCA and skin reactions were evoked at the same time in the dorsal skin of a rat. Administrations of glucocorticoids inhibited not only the PCA but also the skin reactions caused by histamine, serotonin and leukotriene (LT) C4 significantly. It is suggested, therefore, that glucocorticoids inhibit the increase of vascular permeability non-specifically. This action of glucocorticoids might contribute at least in part to its inhibitory effect on the PCA.

摘要

研究了氢化可的松、泼尼松龙和地塞米松对IgE抗体介导的同种被动皮肤过敏反应（PCA）以及介质诱导的皮肤反应的影响。在大鼠背部皮肤同时诱发PCA和皮肤反应。给予糖皮质激素不仅显著抑制了PCA，还抑制了由组胺、5-羟色胺和白三烯（LT）C4引起的皮肤反应。因此，提示糖皮质激素非特异性地抑制血管通透性增加。糖皮质激素的这一作用可能至少部分地促成了其对PCA的抑制作用。