Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
Expert Opin Biol Ther. 2021 Nov;21(11):1403-1409. doi: 10.1080/14712598.2021.1913119. Epub 2021 Apr 12.
: Fanconi anemia (FA) is a rare congenital disease that belongs to the family of congenital trilinear bone marrow failure. Most FA patients will suffer bone marrow failure and the main treatment relies on supportive measures or more recently on the use of hematopoietic stem cell transplant. The improvements seen in the management of FA has led women to reach childbearing age and have successful pregnancies. However, these pregnancies are associated with increased complications such as preterm delivery, cesarean delivery, eclampsia and others.: This review highlights on the outcome of pregnancies in FA patients reported in the literature along with practical recommendations.: Multidisciplinary efforts are required to optimize the management of pregnancy in FA patients. Moreover, the development of a set of recommendations to optimize the treatment is highly necessary.
范可尼贫血（FA）是一种罕见的先天性疾病，属于先天性三联骨髓衰竭症。大多数 FA 患者会出现骨髓衰竭，主要治疗方法依赖于支持性措施，或最近依赖于造血干细胞移植。FA 管理方面的改善使得女性能够达到生育年龄并成功怀孕。然而，这些妊娠与早产、剖宫产、子痫等并发症增加有关。
本文主要综述了 FA 患者妊娠结局的相关文献，并提出了一些实用的建议。
多学科的努力是优化 FA 患者妊娠管理所必需的。此外，制定一套优化治疗方案的建议也是非常必要的。
