与 CtBP 二聚体的一对一交流。
Tête-à-tête with CtBP dimers.
机构信息
Cell and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI, USA.
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
出版信息
Structure. 2021 Apr 1;29(4):307-309. doi: 10.1016/j.str.2021.03.006.
Abstract
Jecrois et al. (2020) use cryoelectron microscopy to illuminate the tetrameric conformation of the CtBP2 transcriptional corepressor, a protein frequently overexpressed in human cancers. The in vivo functional characterization of tetramer-destabilizing mutants indicates that tetramerization is a physiologically important process, critical for CtBP control of gene regulation and cell migration.
摘要
Jecrois 等人（2020 年）使用冷冻电子显微镜阐明了 CtBP2 转录共抑制因子的四聚体构象，该蛋白在人类癌症中经常过表达。对四聚体不稳定突变体的体内功能特征分析表明，四聚化是一个生理上重要的过程，对于 CtBP 控制基因调控和细胞迁移至关重要。
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