Xiangya School of Medicine, Central South University, Changsha 410013, China.
Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410013, China.
Viruses. 2024 Jun 19;16(6):988. doi: 10.3390/v16060988.
C-terminal binding protein (CtBP), a transcriptional co-repressor, significantly influences cellular signaling, impacting various biological processes including cell proliferation, differentiation, apoptosis, and immune responses. The CtBP family comprises two highly conserved proteins, CtBP1 and CtBP2, which have been shown to play critical roles in both tumorigenesis and the regulation of viral infections. Elevated CtBP expression is noted in various tumor tissues, promoting tumorigenesis, invasiveness, and metastasis through multiple pathways. Additionally, CtBP's role in viral infections varies, exhibiting differing or even opposing effects depending on the virus. This review synthesizes the advances in CtBP's function research in viral infections and virus-associated tumorigenesis, offering new insights into potential antiviral and anticancer strategies.
C 端结合蛋白（CtBP）是一种转录共抑制因子，对细胞信号转导有重要影响，涉及细胞增殖、分化、凋亡和免疫反应等多种生物学过程。CtBP 家族包括两个高度保守的蛋白 CtBP1 和 CtBP2，它们在肿瘤发生和病毒感染调控中都起着关键作用。CtBP 的表达在各种肿瘤组织中升高，通过多种途径促进肿瘤发生、侵袭和转移。此外，CtBP 在病毒感染中的作用因病毒而异，表现出不同的甚至相反的效果。本综述总结了 CtBP 在病毒感染和病毒相关肿瘤发生中的功能研究进展，为潜在的抗病毒和抗癌策略提供了新的思路。
