The Scripps Research Institute, Department of Molecular Medicine, Jupiter, FL 33458, USA.
Cell. 2021 Apr 1;184(7):1659-1660. doi: 10.1016/j.cell.2021.03.016.
Partial agonism describes the relative efficacy of a drug compared to one that produces a greater response in a particular system; the designation is dependent upon the comparator and the system. In this issue of Cell, Huang et al. describe biophysical approaches to define the signature of GPCR partial agonists, providing direct measures of varying intrinsic efficacy.
部分激动描述了药物与在特定系统中产生更大反应的药物相比的相对效力；该命名取决于比较药物和系统。在本期《细胞》杂志中，Huang 等人描述了定义 GPCR 部分激动剂特征的生物物理方法，提供了内在效力变化的直接测量。
