State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China; Hebei Centre for Disease Control and Prevention, Shijiazhuang, 050021, China.
Hebei Centre for Disease Control and Prevention, Shijiazhuang, 050021, China.
Environ Res. 2021 Jun;197:111060. doi: 10.1016/j.envres.2021.111060. Epub 2021 Mar 31.
Short chain chlorinated paraffins (SCCPs) have received increased interest worldwide since they were added to the list of controlled POPs in Annex A of the Stockholm Convention in 2017. Although many toxicological studies have already shown that SCCPs are hepatotoxic, nephrotoxic, and thyrotoxic to rodents, there have been few studies to date that have characterized changes in the metabolic pathways targeted by SCCPs. In this study, a UPLC-Q-TOF-MS based plasma metabolomics approach was used to investigate the toxicity of SCCPs in rats. Liver and kidney injury occurred rapidly after high-dose SCCP exposure, and the most relevant pathways affected were energy metabolism, amino acid metabolism, glycerophospholipid metabolism, nucleotide metabolism, and vitamin B metabolism. Exposure to SCCPs inhibited the tricarboxylic acid cycle and accelerated degradation. Fluctuating levels of phospholipids and nucleotides may have contributed to the neurotoxicity of SCCPs. In addition, the down regulation of folic acid induced by SCCPs may have led to malformations during the early development of laboratory animals. These results suggested that high exposure levels of SCCPs may have serious health risks and more research is needed to assess the health status of relevant occupational groups.
短链氯化石蜡（SCCPs）自 2017 年被列入《斯德哥尔摩公约》附件 A 的受控 POPs 清单以来，引起了全球的广泛关注。尽管许多毒理学研究已经表明 SCCPs 对啮齿动物具有肝毒性、肾毒性和甲状腺毒性，但迄今为止，很少有研究描述 SCCPs 靶向的代谢途径的变化。在这项研究中，采用基于 UPLC-Q-TOF-MS 的血浆代谢组学方法研究了 SCCPs 对大鼠的毒性。高剂量 SCCP 暴露后，肝脏和肾脏损伤迅速发生，受影响最相关的途径是能量代谢、氨基酸代谢、甘油磷脂代谢、核苷酸代谢和维生素 B 代谢。SCCP 的暴露抑制了三羧酸循环并加速了降解。磷脂和核苷酸水平的波动可能导致 SCCP 的神经毒性。此外，SCCP 引起的叶酸下调可能导致实验室动物早期发育过程中的畸形。这些结果表明，SCCP 的高暴露水平可能会对健康造成严重风险，需要进一步研究以评估相关职业群体的健康状况。
