Laboratoire Mer, Molécules, Santé, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Laboratoire Mer, Molécules, Santé, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Mar Pollut Bull. 2021 Jun;167:112295. doi: 10.1016/j.marpolbul.2021.112295. Epub 2021 Mar 31.
The substitution of petrochemical plastics by bio-based and biodegradable plastics are in need of an evaluation for the potential toxic impacts that they can have on marine wildlife. This study aims to assess the toxicological effects of polylactic acid microparticles at two concentrations, 10 and 100 μg/L, during 8 days on the blue mussel, Mytilus edulis. No significant oxidative stress (catalase, glutathione-S-transferase and superoxide dismutase activities), neurotoxicity (acetylcholinesterase), or immunotoxicity (lysosomal membrane stability and acid phosphatase activity) were detectable. The multivariate analysis of metabolomic data allowed us to differentiate the individuals according to the exposure. From the loading plot of OPLS-DA, 48 ions down-regulated in the individuals exposed to microplastics. They were identified based on HRMS data as glycerophospholipids.
需要对生物基和可生物降解塑料替代石化塑料对海洋野生动物可能产生的潜在毒性影响进行评估。本研究旨在评估聚乳酸微粒在两个浓度，10 和 100μg/L 下，对贻贝 Mytilus edulis 进行 8 天的毒性作用。未检测到明显的氧化应激（过氧化氢酶、谷胱甘肽-S-转移酶和超氧化物歧化酶活性）、神经毒性（乙酰胆碱酯酶）或免疫毒性（溶酶体膜稳定性和酸性磷酸酶活性）。代谢组学数据的多元分析允许我们根据暴露情况将个体区分开来。从 OPLS-DA 的加载图中，可以看出暴露于微塑料的个体中 48 种离子下调。基于 HRMS 数据，它们被鉴定为甘油磷脂。
