中国济南居民的血清短链和中链氯化石蜡与男性肾功能有关。
Male renal functions are associated with serum short- and medium-chain chlorinated paraffins in residents from Jinan, China.
机构信息
School of Environmental Science and Engineering, Shandong University, Binhai Road 72, Qingdao 266237, China.
Environmental Research Institute, Shandong University, Binhai Road 72, Qingdao 266237, China.
出版信息
Environ Int. 2021 Aug;153:106514. doi: 10.1016/j.envint.2021.106514. Epub 2021 Mar 30.
BACKGROUND
Chlorinated paraffins (CPs) are contaminants ubiquitously detected in environmental samples, and reports addressing CPs in human samples are expanding. While CP exposure was suggested to impair kidney function by in vivo/in vitro experiments, epidemiological evidence is lacking.
OBJECTIVE
To examine the associations between serum total short-chain CP and medium-chain CP concentrations (∑SCCPs and ∑MCCPs) with human kidney function.
METHODS
The study samples were obtained from 387 participants living in Jinan, North China. We quantified ∑SCCPs and ∑MCCPs in serum samples and evaluated the kidney function of included subjects by estimated glomerular filtration rate (eGFR). The associations between serum ∑SCCPs, ∑MCCPs and eGFR were estimated using multivariable linear regression and logistic regression. The possible gender-dependent effects were studied by stratified analysis.
RESULTS
After adjusting for age, education, smoking status, drinking status, body mass index (BMI), family history of chronic kidney disease (CKD), fasting serum glucose, systolic blood pressure and diastolic blood pressure, higher concentrations of serum ∑SCCPs and ∑MCCPs were associated with higher male eGFR (β = 3.13 mL/min/1.73 m per one ln-unit increase of serum ∑SCCPs, 95%CI: 1.72, 4.54, p = 0.016; β = 3.52 mL/min/1.73 m per one ln-unit increase of serum ∑MCCPs, 95%CI: 1.89, 5.17, p = 0.011). Associations between serum ∑SCCPs, ∑MCCPs and female eGFR were null. Comparing higher (above the median serum CP levels) vs. lower exposure groups, serum ∑SCCPs and ∑MCCPs were associated with an elevated risk of glomerular hyperfiltration (GH, eGFR ≥ 135 mL/min/1.73 m), which was associated with glomerular damage and represented as an early stage of chronic kidney disease (OR = 2.98; 95% CI: 1.24, 4.71 for SCCPs; OR = 3.25; 95% CI: 1.20, 5.29 for MCCPs).
CONCLUSIONS
Our study suggests that male serum ∑SCCPs and ∑MCCPs are associated with an increased risk of GH, indicating early-stage kidney impairment.
背景
短链氯化石蜡 (SCCPs) 和中链氯化石蜡 (MCCPs) 是环境样本中普遍存在的污染物，有关人类样本中 SCCPs 和 MCCPs 的报道也在不断增加。虽然体内/体外实验表明 CP 暴露会损害肾功能，但缺乏流行病学证据。
目的
研究血清总短链 CP 和中链 CP 浓度（∑SCCPs 和 ∑MCCPs）与人体肾功能之间的关系。
方法
本研究样本来自中国北方济南市的 387 名参与者。我们对血清样本中的∑SCCPs 和∑MCCPs 进行了定量分析，并通过估算肾小球滤过率 (eGFR) 评估了纳入研究对象的肾功能。采用多元线性回归和 logistic 回归分析血清∑SCCPs、∑MCCPs 与 eGFR 之间的关系。通过分层分析研究了可能存在的性别依赖性影响。
结果
在调整了年龄、教育程度、吸烟状况、饮酒状况、体重指数（BMI）、慢性肾脏病（CKD）家族史、空腹血糖、收缩压和舒张压后，血清∑SCCPs 和∑MCCPs 浓度与男性 eGFR 升高相关（血清∑SCCPs 每增加一个自然对数值单位，男性 eGFR 升高 3.13mL/min/1.73m，95%CI：1.72，4.54，p=0.016；血清∑MCCPs 每增加一个自然对数值单位，男性 eGFR 升高 3.52mL/min/1.73m，95%CI：1.89，5.17，p=0.011）。血清∑SCCPs 和∑MCCPs 与女性 eGFR 之间无关联。与低暴露组相比，血清∑SCCPs 和∑MCCPs 处于较高水平（高于中位血清 CP 水平）与肾小球高滤过（GH，eGFR≥135mL/min/1.73m）风险升高相关，GH 代表肾小球损伤，是慢性肾脏病的早期阶段（SCCPs 的 OR=2.98；95%CI：1.24，4.71；MCCPs 的 OR=3.25；95%CI：1.20，5.29）。
结论
本研究表明，男性血清∑SCCPs 和∑MCCPs 与 GH 风险增加有关，表明肾脏早期受损。
Zotero 插件