School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand.
Molecules. 2021 Mar 14;26(6):1608. doi: 10.3390/molecules26061608.
Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5--acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.
槲皮素是一种类黄酮，存在于许多植物材料中，包括常见的食用水果和蔬菜。该化合物以其广泛的生物活性而闻名。在这项研究中，合成了槲皮素的 5-酰基衍生物，并评估了它们对 HCT116 结肠癌细胞和 MDA-MB-231 乳腺癌细胞系的增殖活性；以及它们对 2,2'-联氮双(3-乙基苯并噻唑啉-6-磺酸)（ABTS）自由基阳离子和 2,2-二苯基-1-苦基肼（DPPH）自由基的清除活性。发现四种衍生物在保持自由基清除活性的同时，提高了对槲皮素的增殖活性。
