生长激素与听觉通路：神经调制与神经再生。
Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration.
机构信息
Otolaryngology, Medical Center Foltra, 15886 Teo, Spain.
Scientific Direction, Medical Center Foltra, 15886 Teo, Spain.
出版信息
Int J Mol Sci. 2021 Mar 11;22(6):2829. doi: 10.3390/ijms22062829.
Abstract
Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial effects in humans presented and substantiated in the main text, although they should not exaggerate the main conclusions.
摘要
生长激素（GH）在胚胎期的听觉发育中起着重要作用。外源物质，如声音、噪音、药物或创伤，可以诱导这种激素的释放，以发挥保护作用，并刺激其他保护听觉通路的介质。此外，GH 缺乏会导致听力损失或中枢听觉处理障碍。有一些有前途的动物研究表明，外源性 GH 在听力损伤中的应用可能具有再生作用，这在体内和体外研究中都得到了证实，甚至有一些研究在文中展示了人类的有益效果，尽管它们不应夸大主要结论。
相似文献
1
Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration.生长激素与听觉通路：神经调制与神经再生。
Int J Mol Sci. 2021 Mar 11;22(6):2829. doi: 10.3390/ijms22062829.
2
Insulin-like growth factor 1 promotes cochlear synapse regeneration after excitotoxic trauma in vitro.胰岛素样生长因子1在体外促进兴奋性毒性损伤后耳蜗突触再生。
Hear Res. 2019 Mar 15;374:5-12. doi: 10.1016/j.heares.2019.01.008. Epub 2019 Jan 17.
3
Auditory neuropathy--neural and synaptic mechanisms.听觉神经病——神经和突触机制。
Nat Rev Neurol. 2016 Mar;12(3):135-49. doi: 10.1038/nrneurol.2016.10. Epub 2016 Feb 19.
4
Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing.衰老耳蜗中的突触病变：听觉时间包络处理的早期神经缺陷特征。
J Neurosci. 2018 Aug 8;38(32):7108-7119. doi: 10.1523/JNEUROSCI.3240-17.2018. Epub 2018 Jul 5.
5
Central auditory pathology.中枢听觉病理学
Otolaryngol Head Neck Surg. 1986 Oct;95(3 Pt 2):363-424. doi: 10.1177/01945998860953P201.
6
Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus.选择性毛细胞消融和噪声暴露导致耳蜗及耳蜗核出现不同模式的变化。
Neuroscience. 2016 Sep 22;332:242-57. doi: 10.1016/j.neuroscience.2016.07.001. Epub 2016 Jul 9.
7
Effects of cochlear synaptopathy on middle-ear muscle reflexes in unanesthetized mice.耳蜗突触病变对未麻醉小鼠中耳肌肉反射的影响。
Hear Res. 2018 Jun;363:109-118. doi: 10.1016/j.heares.2018.03.012. Epub 2018 Mar 13.
8
Sensorineural hearing loss during development: morphological and physiological response of the cochlea and auditory brainstem.发育过程中的感音神经性听力损失：耳蜗和听觉脑干的形态学及生理学反应
Hear Res. 1999 Feb;128(1-2):147-65. doi: 10.1016/s0378-5955(98)00209-3.
9
Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain.生长激素和胰岛素样生长因子-I与成人大脑的神经保护、再生及功能可塑性相关的各个方面。
ScientificWorldJournal. 2006 Jan 18;6:53-80. doi: 10.1100/tsw.2006.22.
10
The auditory pathology of anoxia.缺氧的听觉病理学
Otolaryngology. 1978 Jan-Feb;86(1):ORL-27-39. doi: 10.1177/019459987808600109.
引用本文的文献
1
Otolaryngological Problems Among Patients with Growth Hormone Deficiency-A Systematic Review.生长激素缺乏症患者的耳鼻喉科问题——一项系统综述
J Clin Med. 2025 Apr 29;14(9):3064. doi: 10.3390/jcm14093064.
2
Single cell RNA sequencing provides novel cellular transcriptional profiles and underlying pathogenesis of presbycusis.单细胞 RNA 测序为 presbycusis 提供了新的细胞转录谱和潜在的发病机制。
BMC Med Genomics. 2024 Sep 30;17(1):237. doi: 10.1186/s12920-024-02001-7.
3
Insulin-like Growth Factor 1 Signaling in Mammalian Hearing.胰岛素样生长因子 1 信号在哺乳动物听力中的作用。
Genes (Basel). 2021 Sep 29;12(10):1553. doi: 10.3390/genes12101553.
本文引用的文献
1
Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area.生长激素促进实验性中风后的运动功能，并增强梗死周围区域的促进恢复机制。
Int J Mol Sci. 2020 Jan 17;21(2):606. doi: 10.3390/ijms21020606.
2
Noise-induced loss of sensory hair cells is mediated by ROS/AMPKα pathway.噪声诱导的感觉毛细胞损失是由 ROS/AMPKα 通路介导的。
Redox Biol. 2020 Jan;29:101406. doi: 10.1016/j.redox.2019.101406. Epub 2019 Dec 14.
3
Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus.生长激素和康复治疗后皮质切除大鼠运动功能恢复的相关因素：纹状体和丘脑的皮质细胞增殖及巢蛋白和肌动蛋白的表达。
Int J Mol Sci. 2019 Nov 16;20(22):5770. doi: 10.3390/ijms20225770.
4
Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling.生长激素对红藻氨酸兴奋性毒性的神经保护作用是通过 Notch/PTEN/Akt 信号转导介导的。
Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4532-4547. doi: 10.1167/iovs.19-27473.
5
Regenerative Effect of Growth Hormone (GH) in the Retina after Kainic Acid Excitotoxic Damage.生长激素（GH）在红藻氨酸兴奋性损伤后对视网膜的再生作用。
Int J Mol Sci. 2019 Sep 10;20(18):4433. doi: 10.3390/ijms20184433.
6
Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1.毛细胞在小鼠耳石器中的转录组和表观遗传调控及其由 Atoh1 增强。
Elife. 2019 Apr 29;8:e44328. doi: 10.7554/eLife.44328.
7
Growth Hormone Improves Nerve Regeneration, Muscle Re-innervation, and Functional Outcomes After Chronic Denervation Injury.生长激素可改善慢性去神经损伤后神经再生、肌肉再支配和功能恢复。
Sci Rep. 2019 Feb 28;9(1):3117. doi: 10.1038/s41598-019-39738-6.
8
Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage.哺乳动物内耳毛细胞在对抗噪声性耳蜗损伤中的保护作用。
Neural Plast. 2018 Jul 15;2018:3170801. doi: 10.1155/2018/3170801. eCollection 2018.
9
Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice.CBA小鼠噪声性听力损失确立很久后空间学习障碍的海马机制
Front Syst Neurosci. 2018 Jul 24;12:35. doi: 10.3389/fnsys.2018.00035. eCollection 2018.
10
Hearing Loss in Acromegaly - A Review.肢端肥大症中的听力损失——综述
Int Arch Otorhinolaryngol. 2018 Jul;22(3):313-316. doi: 10.1055/s-0037-1603619. Epub 2017 Jun 16.
Zotero 插件