Ganguly Abhrajit, Ofman Gaston, Vitiello Peter F
Center for Pregnancy and Newborn Research, Department of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Children (Basel). 2021 Mar 11;8(3):213. doi: 10.3390/children8030213.
Reactive oxygen species (ROS) have been the focus of redox research in the realm of oxidative neonatal respiratory diseases such as bronchopulmonary dysplasia (BPD). Over the years, nitric oxide (NO) and carbon monoxide (CO) have been identified as important gaseous signaling molecules involved in modulating the redox homeostasis in the developing lung. While animal data targeting aspects of these redox pathways have been promising in treating and/or preventing experimental models of neonatal lung disease, none are particularly effective in human neonatal clinical trials. In recent years, hydrogen sulfide (HS) has emerged as a novel gasotransmitter involved in a magnitude of cellular signaling pathways and functions. The importance of HS signaling may lie in the fact that early life-forms evolved in a nearly anoxic, sulfur-rich environment and were dependent on HS for energy. Recent studies have demonstrated an important role of HS and its synthesizing enzymes in lung development, which normally takes place in a relatively hypoxic intrauterine environment. In this review, we look at clues from evolution and explore the important role that the HS signaling pathway may play in oxidative neonatal respiratory diseases and discuss future opportunities to explore this phenomenon in the context of neonatal chronic lung disease.
活性氧（ROS）一直是氧化型新生儿呼吸系统疾病（如支气管肺发育不良，BPD）领域氧化还原研究的重点。多年来，一氧化氮（NO）和一氧化碳（CO）已被确认为参与调节发育中肺部氧化还原稳态的重要气体信号分子。尽管针对这些氧化还原途径各方面的动物实验数据在治疗和/或预防新生儿肺部疾病实验模型方面很有前景，但在人类新生儿临床试验中都不是特别有效。近年来，硫化氢（HS）已成为一种新型气体信号分子，参与多种细胞信号通路和功能。HS信号的重要性可能在于早期生命形式是在几乎缺氧、富含硫的环境中进化的，并且依赖HS获取能量。最近的研究表明，HS及其合成酶在通常发生在相对低氧的子宫内环境中的肺发育中起重要作用。在这篇综述中，我们从进化中寻找线索，探讨HS信号通路在氧化型新生儿呼吸系统疾病中可能发挥的重要作用，并讨论在新生儿慢性肺病背景下探索这一现象的未来机会。
