Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Oxid Med Cell Longev. 2021 Apr 20;2021:6652086. doi: 10.1155/2021/6652086. eCollection 2021.
Together with nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (HS) is now recognized as a vital gaseous transmitter. The ubiquitous distributions of HS-producing enzymes and potent chemical reactivities of HS in biological systems make HS unique in its ability to regulate cellular and organ functions in both health and disease. Acting as an antioxidant, HS can combat oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) and protect the skin from oxidative stress. The aberrant metabolism of HS is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. Furthermore, HS donors and some HS hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. In this review, we discuss recent advances in understanding HS and its antioxidant effects on skin pathology, the roles of altered HS metabolism in skin disorders, and the potential value of HS as a therapeutic intervention in skin diseases.
与一氧化氮（NO）和一氧化碳（CO）一样，硫化氢（HS）现在被认为是一种重要的气体递质。HS 产生酶在生物系统中的广泛分布和 HS 的强大化学反应性使其具有独特的能力，能够调节健康和疾病状态下的细胞和器官功能。作为一种抗氧化剂，HS 可以对抗活性氧物种（ROS）和活性氮物种（RNS）等氧化物质，保护皮肤免受氧化应激。HS 的异常代谢参与了几种皮肤病的发病机制，如血管疾病、银屑病、溃疡、色素紊乱和黑色素瘤。此外，HS 供体和一些 HS 混合物已在许多人类疾病的实验模型中进行了评估，并显示出有希望的治疗效果。在这篇综述中，我们讨论了 HS 的最新研究进展及其对皮肤病理学的抗氧化作用、HS 代谢改变在皮肤疾病中的作用，以及 HS 作为皮肤疾病治疗干预的潜在价值。
