Institute of Molecular Science (ICMOL), Universidad de Valencia, 46980 Paterna, Valencia, Spain.
Departamento de Quimica Organica, Universidad de Cordoba, E-14014 Cordoba, Spain.
Molecules. 2021 Mar 7;26(5):1445. doi: 10.3390/molecules26051445.
Metal-organic frameworks (MOFs) have become one of the versatile solid materials used for a wide range of applications, such as gas storage, gas separation, proton conductivity, sensors and catalysis. Among these fields, one of the more well-studied areas is the use of MOFs as heterogeneous catalysts for a broad range of organic reactions. In the present review, the employment of MOFs as solid catalysts for the Henry reaction is discussed, and the available literature data from the last decade are grouped. The review is organized with a brief introduction of the importance of Henry reactions and structural properties of MOFs that are suitable for catalysis. The second part of the review discusses the use of MOFs as solid catalysts for the Henry reaction involving metal nodes as active sites, while the third section provides data utilizing basic sites (primary amine, secondary amine, amides and urea-donating sites). While commenting on the catalytic results in these two sections, the advantage of MOFs over other solid catalysts is compared in terms of activity by providing turnover number (TON) values and the structural stability of MOFs during the course of the reaction. The final section provides our views on further directions in this field.
金属-有机骨架（MOFs）已成为用途广泛的固体材料之一，可应用于多种领域，如气体储存、气体分离、质子传导、传感器和催化等。在这些领域中，研究较多的领域之一是将 MOFs 用作多种有机反应的多相催化剂。本综述讨论了 MOFs 作为固体催化剂在 Henry 反应中的应用，并对过去十年的相关文献数据进行了分类。综述的组织方式如下：简要介绍 Henry 反应的重要性和适合催化的 MOFs 的结构特性。综述的第二部分讨论了将 MOFs 用作涉及金属节点作为活性位点的 Henry 反应的固体催化剂，第三部分提供了利用碱性位（伯胺、仲胺、酰胺和尿素供体位）的相关数据。在评论这两部分的催化结果时，通过提供转化率（TON）值并比较 MOFs 在反应过程中的结构稳定性，比较了 MOFs 相对于其他固体催化剂在活性方面的优势。最后一部分提供了我们对该领域进一步发展方向的看法。
