Cascone Esther, Longo Simona, Acocella Maria Rosaria
Dipartimento di Chimica e Biologia "Adolfo Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.
ACS Omega. 2022 Jul 15;7(29):25394-25402. doi: 10.1021/acsomega.2c02335. eCollection 2022 Jul 26.
Novel basified graphene oxide and high-porosity monolithic composite aerogels of poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) containing basified graphene oxide (b-eGO) have been prepared as recoverable and reusable catalysts for the Henry reaction in solvent-free conditions at room temperature. The results showed that, although b-eGO was able to promote the reaction, it suffered from reduced stability. On the other hand, PPO/b-eGO aerogels were able to efficiently promote the Henry reaction in solvent-free conditions. The product could be obtained pure without a purification step, and the catalyst was stable for over 15 months and could be easily recycled without losing catalytic efficiency. The stereochemical outcome was further investigated in the presence of PPO/b-eGO. Despite its negligible influence on diastereoselectivity, better efficiency and a sensible reduction of reaction time were observed.
已制备出新型碱化氧化石墨烯以及含有碱化氧化石墨烯（b-eGO）的聚（2,6-二甲基-1,4-亚苯基氧化物）（PPO）高孔隙率整体复合气凝胶，作为用于亨利反应的可回收和可重复使用催化剂，可在室温无溶剂条件下进行该反应。结果表明，尽管b-eGO能够促进反应，但其稳定性有所降低。另一方面，PPO/b-eGO气凝胶能够在无溶剂条件下高效促进亨利反应。无需纯化步骤即可获得纯净产物，并且该催化剂在超过15个月的时间内保持稳定，且可轻松回收而不损失催化效率。在PPO/b-eGO存在的情况下进一步研究了立体化学结果。尽管其对非对映选择性影响可忽略不计，但观察到了更高的效率以及反应时间的显著缩短。
