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前列腺癌的神经内分泌分化与18F-FDG摄取增加并非系统性相关。

Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake.

作者信息

Bauckneht Matteo, Morbelli Silvia, Miceli Alberto, Rebuzzi Sara Elena, Fornarini Giuseppe

机构信息

Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.

Department of Health Sciences (DISSAL), University of Genova, 16132 Genova, Italy.

出版信息

Diagnostics (Basel). 2021 Mar 8;11(3):468. doi: 10.3390/diagnostics11030468.

DOI:10.3390/diagnostics11030468
PMID:33800158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7998830/
Abstract

Neuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT should also be used in cases such as guiding management, as NED is systematically associated with increased glycolysis. We hereby discuss the case of a metastatic prostate cancer patient in which 68Ga-Dotatoc PET/CT revealed the occurrence of NED with low FDG-avidity.

摘要

前列腺癌的神经内分泌分化（NED）是公认的疾病耐药和侵袭性更强的预测指标。利用68Ga标记的生长抑素类似物进行PET/CT成像，可在体内对NED进行功能研究。许多先前的报告表明，18F-FDG PET/CT也应用于指导治疗等情况，因为NED与糖酵解增加系统性相关。我们在此讨论一例转移性前列腺癌患者，其68Ga-奥曲肽PET/CT显示存在低FDG摄取的NED情况。

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The Prognostic Role of Baseline Metabolic Tumor Burden and Systemic Inflammation Biomarkers in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Radium-223: A Proof of Concept Study.
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