Borea Roberto, Favero Diletta, Miceli Alberto, Donegani Maria Isabella, Raffa Stefano, Gandini Annalice, Cremante Malvina, Marini Cecilia, Sambuceti Gianmario, Zanardi Elisa, Morbelli Silvia, Fornarini Giuseppe, Rebuzzi Sara Elena, Bauckneht Matteo
Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Department of Internal Medicine and Medical Specialties (Di.M.I.), University of Genova, 16132 Genova, Italy.
Diagnostics (Basel). 2022 Feb 24;12(3):581. doi: 10.3390/diagnostics12030581.
The role of 2-deoxy-2-[F]fluoro-D-glucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the management of prostate cancer (PCa) patients is increasingly recognised. However, its clinical role is still controversial. Many published studies showed that FDG PET/CT might have a prognostic value in the metastatic castration-resistant phase of the disease, but its role in other settings of PCa and, more importantly, its impact on final clinical management remains to be further investigated. We describe a series of six representative clinical cases of PCa in different clinical settings, but all characterised by a measurable clinical impact of FDG PET/CT on the patients' management. Starting from their clinical history, we report a concise narrative literature review on the advantages and limitations of FDG PET/CT beyond its prognostic value in PCa. What emerges is that in selected cases, this imaging technique may represent a useful tool in managing PCa patients. However, in the absence of dedicated studies to define the optimal clinical setting of its application, no standard recommendations on its use in PCa patients can be made.
2-脱氧-2-[F]氟-D-葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）在前列腺癌（PCa）患者管理中的作用日益受到认可。然而，其临床作用仍存在争议。许多已发表的研究表明，FDG PET/CT在疾病的转移性去势抵抗阶段可能具有预后价值，但其在PCa其他情况下的作用，更重要的是，其对最终临床管理的影响仍有待进一步研究。我们描述了一系列六例不同临床背景下具有代表性的PCa临床病例，但所有病例的特点都是FDG PET/CT对患者管理产生了可衡量的临床影响。从它们的临床病史出发，我们简要叙述了关于FDG PET/CT在PCa中除预后价值之外的优势和局限性的文献综述。结果表明，在某些特定病例中，这种成像技术可能是管理PCa患者的有用工具。然而，由于缺乏专门研究来确定其应用的最佳临床背景，因此无法对其在PCa患者中的使用提出标准建议。
