Molecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital, 20502 Malmö, Sweden.
Cells. 2021 Mar 28;10(4):745. doi: 10.3390/cells10040745.
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork. Mutations in members of the tubulin superfamily are involved in developmental brain disorders, and tubulin activities are the target for various chemotherapies. The intricate functions (game) of tubulins depend on the activities of the GTP-binding domain of α-, β-, and γ-tubulin. This review compares the GTP-binding domains of γ-tubulin, α-tubulin, and β-tubulin and, based on their similarities, recapitulates the known functions and the impact of the γ-tubulin GTP-binding domain in the regulation of the γ-tubulin meshwork and cellular homeostasis.
微管蛋白超家族的成员是 GTPases；GTPases 的活性对于生命是必需的。微管蛋白超家族的成员是微管和 γ-微管网络的组成部分。微管蛋白超家族成员的突变与发育性脑紊乱有关，并且微管蛋白的活性是各种化疗药物的靶点。微管蛋白的复杂功能取决于 α-、β-和 γ-微管蛋白 GTP 结合域的活性。本综述比较了 γ-微管蛋白、α-微管蛋白和 β-微管蛋白的 GTP 结合域，并根据它们的相似性，概括了已知的功能以及 γ-微管蛋白 GTP 结合域在调节 γ-微管蛋白网络和细胞内稳态中的作用。
