γ-微管蛋白作为信号转导分子和具有治疗潜力的网格。
γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential.
机构信息
Molecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, 20502 Sweden.
出版信息
Signal Transduct Target Ther. 2018 Sep 14;3:24. doi: 10.1038/s41392-018-0021-x. eCollection 2018.
Knowledge of γ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in various malignancies, and changes in the gene have been found in patients suffering from brain malformations. This review recapitulates the known functions of γ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer.
γ-微管蛋白的知识正在不断增加，不仅涉及该蛋白参与微管核形成的细胞功能，还涉及其他功能。γ-微管蛋白的表达在各种恶性肿瘤中发生改变，并且在患有脑畸形的患者中发现了 基因的变化。本文综述了 γ-微管蛋白在细胞动态平衡中的已知功能，并讨论了该蛋白对疾病发展和癌症的可能影响。
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