Saito Jumpei, Miyamoto Sayaka, Yamada Mayumi, Yamatani Akimasa, Ruiz Fabrice, Vallet Thibault
National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
ClinSearch, 110 Avenue Pierre Brossolette, 92240 Malakoff, France.
Pharmaceutics. 2021 Mar 6;13(3):345. doi: 10.3390/pharmaceutics13030345.
Urinary tract infection (UTI) is a common health care-associated adverse event and the leading nosocomial complication following pediatric urological surgery. While continuous antimicrobial prophylaxis effectively reduces the risk of UTI following such a surgery, non-adherence is common and represents a distinct clinical entity that is associated with renal scarring. Acceptability is likely to have a significant impact on patient adherence. Herein we used a validated data-driven approach-the ClinSearch acceptability score test (CAST)-to investigate the acceptability of cefaclor, an oral antibiotic widely used for the prevention of pediatric UTI in Japan. Standardized observer reports were collected for 58 intakes of cefaclor 10% fine granules in patients aged from 0 to 17 years. The medicine was classified as positively accepted on the acceptability reference framework. According to the percentage of the prescribed dose taken reported at the end of the treatment, patients exhibited good adherence to this well-accepted medicine. Nonetheless, requirements for greater dosing frequency or poor acceptability in certain patients could affect adherence. Acceptability should be established to ensure patient adherence to medicines used for long-term prophylaxis and consequently guarantee the safety and efficacy of the treatment.
尿路感染（UTI）是一种常见的与医疗保健相关的不良事件，也是小儿泌尿外科手术后主要的医院内并发症。虽然持续预防性使用抗菌药物可有效降低此类手术后发生UTI的风险，但不依从情况很常见，并且代表了一种与肾瘢痕形成相关的独特临床实体。可接受性可能会对患者的依从性产生重大影响。在此，我们使用了一种经过验证的数据驱动方法——临床搜索可接受性评分测试（CAST），来研究头孢克洛（一种在日本广泛用于预防小儿UTI的口服抗生素）的可接受性。收集了58例0至17岁患者服用10%头孢克洛细颗粒剂的标准化观察者报告。在可接受性参考框架下，该药物被归类为被积极接受。根据治疗结束时报告的服用规定剂量的百分比，患者对这种被广泛接受的药物表现出良好的依从性。尽管如此，更高的给药频率要求或某些患者的可接受性差可能会影响依从性。应确定可接受性，以确保患者坚持使用用于长期预防的药物，从而保证治疗的安全性和有效性。
