Vallet Thibault, Bensouda Yahya, Saito Jumpei, Mathiesen Liv, Pokharkar Varsha, Klingmann Viviane, Peak Matthew, Elhamdaoui Omar, Yamatani Akimasa, Ivanovic Ivana, Sajith Manjusha, Münch Juliane, Bracken Louise, Duncan Jennifer Claire, Salunke Smita, Wang Siri, Ruiz Fabrice
ClinSearch, 92240 Malakoff, France.
Faculty of Pharmacy and Medicine, Mohammed V University in Rabat, Rabat 10170, Morocco.
Pharmaceutics. 2021 Oct 18;13(10):1721. doi: 10.3390/pharmaceutics13101721.
Antibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on compliance. Herein we used a multivariate approach, considering simultaneously the many aspects of acceptability to explore the drivers of oral antibiotic acceptability in children under twelve, especially in toddlers and in preschoolers. Based on 628 real-life observer reports of the intake of 133 distinct medicines, the acceptability reference framework highlighted the influence of many factors such as age and sex of patients, previous exposure to treatment, place of administration, administration device, flavor agent in excipients and active pharmaceutical ingredient. These findings from an international observational study emphasize the multidimensional nature of acceptability. Therefore, it is crucial to consider all these different aspects for assessing this multi-faceted concept and designing or prescribing a medicine in order to reach adequate acceptability in the target population.
抗生素是儿童中最常用的处方药之一。坚持使用这些药物进行治疗对于预防耐药菌的出现至关重要，而耐药菌是一种全球健康威胁。在儿童中，药物的可接受性可能对依从性产生重大影响。在此，我们采用了一种多变量方法，同时考虑可接受性的诸多方面，以探究12岁以下儿童，尤其是幼儿和学龄前儿童口服抗生素可接受性的驱动因素。基于628份关于133种不同药物摄入情况的真实观察报告，可接受性参考框架突出了许多因素的影响，如患者的年龄和性别、既往治疗经历、给药地点、给药装置、辅料中的调味剂以及活性药物成分。这项国际观察性研究的结果强调了可接受性的多维度性质。因此，在评估这个多方面的概念以及设计或开处方药物时，考虑所有这些不同方面对于在目标人群中达到足够的可接受性至关重要。
