Park Jinkyung, Jeong Dahee, Song Meeryoung, Kim Bonglee
College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Antioxidants (Basel). 2021 Mar 27;10(4):527. doi: 10.3390/antiox10040527.
Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with "cancer metastasis" and "herbal medicine" as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs.
转移是癌症相关死亡的主要原因。尽管其致死率很高，但尚未开展一项涵盖草药抗转移作用的全面研究。本研究的目的是调查和评估草药对包括肺癌、结直肠癌、胃癌、肝癌和乳腺癌在内的五种主要癌症的抗转移疗效。我们使用PubMed、谷歌学术和科学网，以“癌症转移”和“草药”为关键词，收集了五年内发表的文章。相应地，对16项肺癌、23项结直肠癌、10项胃癌、10项肝癌和18项乳腺癌研究进行了系统综述。草药通过靶向多种机制（如上皮-间质转化（EMT）、活性氧（ROS）和血管生成）来减弱转移潜能。具体而言，这些药物调节了与转移相关的因子，如基质金属蛋白酶（MMP）、丝氨酸-苏氨酸蛋白激酶/细胞外调节蛋白激酶（AKT/ERK）、血管生成因子和趋化因子。总体而言，本研究是首次全面调查草药对五种主要癌症抗转移作用的综述，提供了实验模型、剂量和疗程以及作用机制。草药可能是抗转移药物的有力候选者。
