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角膜炎,病理学,诊断与治疗。

Keratitis, Pathology, Diagnosis and Treatment.

作者信息

Fanselow Nicholas, Sirajuddin Nadia, Yin Xiao-Tang, Huang Andrew J W, Stuart Patrick M

机构信息

Department of Ophthalmology, Saint Louis University, Saint Louis, MO 63104, USA.

Department of Ophthalmology and Visual Sciences, Washington University, Saint Louis, MO 63110, USA.

出版信息

Pathogens. 2021 Mar 10;10(3):323. doi: 10.3390/pathogens10030323.

Abstract

keratitis is an unusual corneal infection that is recently increasing in frequency and is often contracted by contact lens wearers, someone who experienced recent eye trauma, or someone exposed to contaminated waters. survive in air, soil, dust, and water. Therefore, eye trauma and poor contact lens hygiene practices lead to the entrapment of debris and thus infection. keratitis results in severe eye pain, inflammation, and defects of the epithelium and stroma that can potentially result in vision loss if not diagnosed early and treated promptly. The disease can be diagnosed using corneal scrape/biopsy, polymerase chain reactions, impression cytology, or in vivo confocal microscopy. Once diagnosed, it is usually treated with an antimicrobial combination therapy of biguanide and aromatic diadine eye drops for several months. Advanced stages of the disease result in vision loss and the need for corneal transplants. Avoiding the risk factors and diagnosing the disease early are the most effective ways to combat keratitis.

摘要

角膜炎是一种不常见的角膜感染,其发病频率近来呈上升趋势,常发生于隐形眼镜佩戴者、近期有眼外伤经历者或接触过受污染水源的人。它可在空气、土壤、灰尘和水中存活。因此,眼外伤和不良的隐形眼镜卫生习惯会导致碎屑滞留,进而引发感染。角膜炎会导致严重的眼痛、炎症以及上皮和基质缺损,如果不及早诊断和及时治疗,可能会导致视力丧失。该疾病可通过角膜刮片/活检、聚合酶链反应、印片细胞学检查或活体共聚焦显微镜检查来诊断。一旦确诊,通常会使用双胍类和芳香二碘化物眼药水进行抗菌联合治疗数月。疾病的晚期会导致视力丧失,需要进行角膜移植。避免危险因素并尽早诊断该疾病是对抗角膜炎最有效的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a471/7998329/778e559237d0/pathogens-10-00323-g001.jpg

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