在沙特阿拉伯，25-羟维生素 D 与 2 型糖尿病患者的糖化血红蛋白有关吗？一项基于人群的研究。
Is 25-Hydroxyvitamin D Associated with Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus in Saudi Arabia? A Population Based Study.
机构信息
Reserach Chairs Program, Princess Nora Bent Abdullah Chair for Women's Health Research, King Saud University, Riyadh 231831, Saudi Arabia.
Department of Family & Community Medicine, College of Medicine, King Saud University, Riyadh 7065, Saudi Arabia.
出版信息
Int J Environ Res Public Health. 2021 Mar 10;18(6):2805. doi: 10.3390/ijerph18062805.
BACKGROUND
Saudi Arabia has a high burden of diabetes mellitus and vitamin D deficiency. The objective of this study was to explore the association between glycosylated hemoglobin and 25-hydroxyvitamin D in patients with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia.
METHODS
An interview based cross-sectional study was conducted on 606 patients with type 2 diabetes, aged 30-75 years, visiting primary health care centers. Blood samples were collected for measuring HbA1c, 25(OH)D and bone and lipid markers. Multivariable linear regression analysis was conducted to explore the association between HbA1c and 25(OH)D.
RESULTS
The mean (±SD) levels for HbA1c and 25(OH) D were 7.69 (±1.77) and 44.28 (±23.06), respectively. Around 55% of patients had uncontrolled HbA1c (>7.0), whereas vitamin D deficiency (<50 nmol/L) was found in 52.3% (=317). Multiple linear regression analysis found that a unit increase in vitamin D levels and parathyroid hormone levels was associated with -0.17 (-0.02, -0.01, < 0.001) and -0.20 (-2.66, -1.18, < 0.001) unit decrease in levels of HbA1c, respectively. Similarly, increasing age was associated with -0.15 (-0.01, -0.04, = 0.002) unit decrease in HbA1c levels, whereas unit increases in serum alkaline phosphatase, calcium and diabetes duration were associated with 0.22 (0.01, 0.02, < 0.001), 0.14 (1.03, 3.88, = 0.001) and 0.26 (0.42, 0.78, < 0.001) unit increase in HbA1c levels, respectively.
CONCLUSION
HbA1c levels are associated with 25-hydroxyvitamin D levels. For better control of HbA1c levels, it is important to maintain 25-hydroxyvitamin D level and bone markers within normal range.
背景
沙特阿拉伯的糖尿病和维生素 D 缺乏症负担沉重。本研究的目的是探讨沙特阿拉伯利雅得 2 型糖尿病（T2DM）患者糖化血红蛋白（HbA1c）与 25-羟维生素 D 之间的关系。
方法
对 606 名年龄在 30-75 岁之间的 2 型糖尿病患者进行了基于访谈的横断面研究，这些患者就诊于初级保健中心。采集血样以测量 HbA1c、25（OH）D 和骨及脂质标志物。采用多元线性回归分析探讨 HbA1c 与 25（OH）D 之间的关系。
结果
HbA1c 和 25（OH）D 的平均（±SD）水平分别为 7.69（±1.77）和 44.28（±23.06）。约 55%的患者 HbA1c 控制不佳（>7.0），而维生素 D 缺乏（<50nmol/L）的患者占 52.3%（=317）。多元线性回归分析发现，维生素 D 水平和甲状旁腺激素水平每增加一个单位，HbA1c 水平就会分别降低 0.17（-0.02，-0.01，<0.001）和 0.20（-2.66，-1.18，<0.001）个单位。同样，年龄每增加一岁，HbA1c 水平就会降低 0.15（-0.01，-0.04，=0.002）个单位，而血清碱性磷酸酶、钙和糖尿病病程每增加一个单位，HbA1c 水平就会分别增加 0.22（0.01，0.02，<0.001）、0.14（1.03，3.88，=0.001）和 0.26（0.42，0.78，<0.001）个单位。
结论
HbA1c 水平与 25-羟维生素 D 水平相关。为了更好地控制 HbA1c 水平，保持 25-羟维生素 D 水平和骨标志物在正常范围内很重要。
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