Hu Zhiwei, Chen Jin'an, Sun Xinjuan, Wang Lei, Wang Aiping
Department of Endocrinology, 454 Hospital Affiliated to People's Liberation Army, Nanjing, Jiangsu Province, China.
Medicine (Baltimore). 2019 Apr;98(14):e14970. doi: 10.1097/MD.0000000000014970.
Conflicting evidence exists on the effect of vitamin D supplementation on glucose metabolism in subjects with type 2 diabetes (T2D). Therefore, this meta-analysis focuses on the relationship between vitamin D intervention and glycaemic control in subjects with T2D.
We reviewed available randomized controlled trials (RCTs) studies from the establishment time of each database to March 31, 2018. Stata 13.0 software was used to evaluate the included literature.
Finally, a total of 19 RCT studies involving 747 intervention subjects and 627 placebo controls were included in this meta-analysis. Meta-analysis results showed that compared with the control group, the short-term vitamin D supplementation group had a decline in hemoglobin A1c (HbA1c), insulin resistance, and insulin. The Standard Mean Difference (SMD) (95% CI [95% confidence interval]) of HbA1c, insulin resistance, and insulin were -0.17 (-0.29, -0.05), -0.75 (-0.97, -0.53), -0.57 (-0.78, -0.35), respectively with all P value <.05. But there were no significant differences in long-term follow-up vitamin D intervention.
Vitamin D supplementation in T2D patients can improve HbA1c, insulin resistance, and insulin in short-term intervention, suggesting that vitamin D can be considered as a therapeutic agent along with the other treatments for T2D.
关于补充维生素D对2型糖尿病（T2D）患者糖代谢的影响，存在相互矛盾的证据。因此，本荟萃分析聚焦于维生素D干预与T2D患者血糖控制之间的关系。
我们检索了从各数据库建立时间至2018年3月31日的现有随机对照试验（RCT）研究。使用Stata 13.0软件对纳入文献进行评估。
最终，本荟萃分析共纳入19项RCT研究，涉及747名干预对象和627名安慰剂对照。荟萃分析结果显示，与对照组相比，短期补充维生素D组的糖化血红蛋白（HbA1c）、胰岛素抵抗和胰岛素水平有所下降。HbA1c、胰岛素抵抗和胰岛素的标准均差（SMD）（95%置信区间[95%CI]）分别为-0.17（-0.29，-0.05）、-0.75（-0.97，-0.53）、-0.57（-0.78，-0.35），所有P值均<.05。但长期随访维生素D干预无显著差异。
T2D患者短期补充维生素D可改善HbA1c、胰岛素抵抗和胰岛素水平，提示维生素D可与T2D的其他治疗方法一起被视为一种治疗药物。
