Department of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.
Int J Mol Sci. 2021 Mar 10;22(6):2804. doi: 10.3390/ijms22062804.
Blood vessels are essential for the formation and maintenance of almost all functional tissues. They play fundamental roles in the supply of oxygen and nutrition, as well as development and morphogenesis. Vascular endothelial cells are the main factor in blood vessel formation. Recently, research findings showed heterogeneity in vascular endothelial cells in different tissue/organs. Endothelial cells alter their gene expressions depending on their cell fate or angiogenic states of vascular development in normal and pathological processes. Studies on gene regulation in endothelial cells demonstrated that the activator protein 1 (AP-1) transcription factors are implicated in angiogenesis and vascular development. In particular, it has been revealed that JunB (a member of the AP-1 transcription factor family) is transiently induced in endothelial cells at the angiogenic frontier and controls them on tip cells specification during vascular development. Moreover, JunB plays a role in tissue-specific vascular maturation processes during neurovascular interaction in mouse embryonic skin and retina vasculatures. Thus, JunB appears to be a new angiogenic factor that induces endothelial cell migration and sprouting particularly in neurovascular interaction during vascular development. In this review, we discuss the recently identified role of JunB in endothelial cells and blood vessel formation.
血管对于几乎所有功能性组织的形成和维持都是必不可少的。它们在供应氧气和营养物质、发育和形态发生方面发挥着基本作用。血管内皮细胞是血管形成的主要因素。最近的研究结果表明，不同组织/器官的血管内皮细胞存在异质性。内皮细胞根据其细胞命运或正常和病理过程中血管发育的血管生成状态改变其基因表达。对内皮细胞中基因调控的研究表明，激活蛋白 1（AP-1）转录因子参与血管生成和血管发育。特别是，已经揭示出在血管生成前沿的内皮细胞中瞬时诱导 JunB（AP-1 转录因子家族的成员），并在血管发育过程中控制尖端细胞的特异性。此外，JunB 在小鼠胚胎皮肤和视网膜血管中的神经血管相互作用过程中发挥作用，促进组织特异性血管成熟过程。因此，JunB 似乎是一种新的血管生成因子，可诱导内皮细胞迁移和发芽，特别是在血管发育过程中的神经血管相互作用中。在这篇综述中，我们讨论了 JunB 在血管内皮细胞和血管形成中的新发现的作用。
