Han Mengzhen, Zhang Meina, Wang Xiaowei, Bai Xue, Yue Tianli, Gao Zhenpeng
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Nutrients. 2021 Mar 17;13(3):971. doi: 10.3390/nu13030971.
Obesity and hyperglycemia are two serious chronic diseases that are increasing in incidence worldwide. This research aimed to develop a fermented cloudy apple juice with good hyperglycemia intervention activities. Here, cloudy apple juice (CAJ), cloudy apple juice rich in polyphenols (CAJP) and fermented cloudy apple juice rich in polyphenols (FCAJP) were prepared sequentially, and then the effects of the three apple juices on weight, lipid level, gut microbiota composition and intestinal tract health were evaluated for obese mice induced by a high-fat diet. The research findings revealed that the FCAJP showed potential to inhibit the weight gain of mice, reduce fat accumulation, and regulate the blood lipid levels of obese mice by decreasing the ratio of the Firmicutes/Bacteroidotas, improving the Sobs, Ace, and Chao indexes of the gut microbiota and protecting intestinal tract health. In addition, the FCAJP augmented the abundance of Akkermansia and Bacteroides, which were positively related to SCFAs in cecal contents. This study inferred that FCAJP could be developed as a healthy food for preventing obesity and hyperglycemia.
肥胖和高血糖是两种严重的慢性疾病，在全球范围内发病率不断上升。本研究旨在开发一种具有良好高血糖干预活性的发酵混浊苹果汁。在此，依次制备了混浊苹果汁（CAJ）、富含多酚的混浊苹果汁（CAJP）和富含多酚的发酵混浊苹果汁（FCAJP），然后评估这三种苹果汁对高脂饮食诱导的肥胖小鼠体重、血脂水平、肠道微生物群组成和肠道健康的影响。研究结果表明，FCAJP具有抑制小鼠体重增加、减少脂肪堆积的潜力，并通过降低厚壁菌门/拟杆菌门的比例、改善肠道微生物群的Sobs、Ace和Chao指数以及保护肠道健康来调节肥胖小鼠的血脂水平。此外，FCAJP增加了阿克曼氏菌属和拟杆菌属的丰度，这与盲肠内容物中的短链脂肪酸呈正相关。本研究推断，FCAJP可开发成为预防肥胖和高血糖的健康食品。
