Research Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, Hungary.
Department of Medical Chemistry, Semmelweis University Medical School, 1071 Budapest, Hungary.
Cells. 2021 Mar 17;10(3):667. doi: 10.3390/cells10030667.
The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC.
在所有癌症亚型中，RAS 最常见的突变异构体是 KRAS。在这篇综述中，我们专注于 KRAS 突变在结直肠癌（CRC）中的特殊作用，旨在收集关于 KRAS 驱动的增强细胞信号转导、体外和体内研究模型以及与转移和癌症干细胞形成等 CRC 发展相关的最新数据。我们试图涵盖 KRAS 突变对与年龄相关的 CRC 发展的不同影响。由于 CRC 的发病率在年轻人中上升，我们回顾了与年龄相关的 CRC 的驱动因素。
