He Kang, Wang Yajing, Zhong Yuejiao, Pan Xiaohua, Si Lixiang, Lu Jianwei
The Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, People's Republic of China.
The Department of Oncology, Jiangsu Cancer Hospital, and the Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research, Nanjing, People's Republic of China.
Onco Targets Ther. 2020 Dec 8;13:12601-12613. doi: 10.2147/OTT.S279312. eCollection 2020.
To investigate the connection between mutant and clinicopathological characteristics in therapy-naïve synchronous metastatic colorectal cancer (mCRC) in Chinese populations when compared with all wild type ( wild type).
A total of 200 patients with therapy-naïve synchronous mCRC (TNM stage: TanyNanyM1) were retrospectively collected as study objects. Primary tumor tissues from 200 mCRC patients were analyzed through next-generation sequencing panel to assess the mutated regions of .
The distribution frequency of gene mutation in our study was 41% , 4% , 11.5% , 0.5% both and . Tumors with any gene mutations (any gene mutations in ), and mutation were more likely to be located in right-sided colon (P=0.007, P=0.008, P=0.026, respectively). For metastasis, tumors with any gene mutations, and mutation were significantly correlated with peritoneal metastasis (P=0.019, P=0.017, P=0.014, respectively), liver-peritoneum metastases (P=0.004, P=0.003, P=0.002, respectively) and multi-organ metastases (P=0.002, P=0.008, P=0.001, respectively). Tumors with all wild type were significantly correlated with distant lymph node-only metastasis. No statistically significant differences were found between clinicopathological characteristics and and mutations.
Our study suggests that clinicopathological characteristics (specifically for metastasis) are related to mutations in therapy-naïve synchronous mCRC population in China. We demonstrated that distant lymph node-only metastasis is visibly linked to all wild-type tumors. We found that patients with any gene mutations, mutation are more likely to carry peritoneal metastasis, liver-peritoneum metastases and multi-organ metastases than those with all wild type. After stratification, mutation, but not mutation, was remarkably associated with peritoneal metastasis, liver-peritoneum metastases, and multi-organ metastases compared to all wild type. These results may be useful for aiding in the prediction of prognosis and choosing the appropriate regimens for therapy.
在中国人群中，研究未经治疗的同时性转移性结直肠癌（mCRC）中突变型与临床病理特征之间的联系，并与所有野生型（野生型）进行比较。
回顾性收集200例未经治疗的同时性mCRC患者（TNM分期：TanyNanyM1）作为研究对象。通过二代测序 panel 分析200例mCRC患者的原发性肿瘤组织，以评估 的突变区域。
本研究中基因突变的分布频率为 41% 、4% 、11.5% 、 及 均为0.5%。发生任何基因突变（ 中任何基因突变）、 及 突变的肿瘤更有可能位于右半结肠（分别为P = 0.007、P = 0.008、P = 0.026）。对于转移情况，发生任何基因突变、 及 突变的肿瘤与腹膜转移（分别为P = 0.019、P = 0.017、P = 0.014）、肝-腹膜转移（分别为P = 0.004、P = 0.003、P = 0.002）及多器官转移（分别为P = 0.002、P = 0.008、P = 0.001）显著相关。所有野生型的肿瘤与仅远处淋巴结转移显著相关。临床病理特征与 及 突变之间未发现统计学显著差异。
我们的研究表明，在中国未经治疗的同时性mCRC人群中，临床病理特征（特别是转移情况）与 突变有关。我们证明仅远处淋巴结转移明显与所有野生型肿瘤相关。我们发现，与所有野生型患者相比，发生任何基因突变、 突变的患者更有可能发生腹膜转移、肝-腹膜转移及多器官转移。分层后，与所有野生型相比， 突变而非 突变与腹膜转移、肝-腹膜转移及多器官转移显著相关。这些结果可能有助于预测预后并选择合适的治疗方案。
