Frolli Alessandro, Ricci Maria Carla, Cavallaro Antonella, Lombardi Agnese, Bosco Antonia, Di Carmine Francesca, Operto Francesca Felicia, Franzese Luisa
Disability Research Centre, University of International Studies of Rome, 00147 Rome, Italy.
FINDS-Italian Neuroscience and Developmental Disorders Foundation, 81040 Caserta, Italy.
Behav Sci (Basel). 2021 Mar 17;11(3):37. doi: 10.3390/bs11030037.
Heavy exposure to cannabis during adolescence can cause significant neurocognitive changes. It can alter emotional responsiveness and social behavior, and cause impairments in sustained attention, learning, working memory (WM), cognitive flexibility, and the speed of information processing. It also has a significant impact on executive functions. In this study we investigated how global cognitive functions can be affected by the frequency of cannabinoid consumption in different categories of consumers (chronic, occasional, and non-users), through the evaluation of executive functions. Statistical analysis showed a significant decrease in performance in working memory tasks and processing speed by subjects using cannabis chronically (group 1) as compared to non-consumers (group 3), and occasional consumers (group 2). Future studies could verify the extent of neurocognitive alterations through re-evaluations with controlled follow-up and the addition of neuro-functional data.
青少年时期大量接触大麻会导致显著的神经认知变化。它会改变情绪反应和社会行为，导致持续注意力、学习、工作记忆（WM）、认知灵活性以及信息处理速度受损。它还对执行功能有重大影响。在本研究中，我们通过评估执行功能，调查了不同类别消费者（长期使用者、偶尔使用者和非使用者）中大麻素消费频率如何影响整体认知功能。统计分析表明，与非消费者（第3组）和偶尔消费者（第2组）相比，长期使用大麻的受试者（第1组）在工作记忆任务和处理速度方面的表现显著下降。未来的研究可以通过对照随访重新评估并增加神经功能数据来验证神经认知改变的程度。
