Masadah Rina, Rauf Syahrul, Pratama Muhammad Yogi, Tiribelli Claudio, Pascut Devis
Department of Pathology Anatomy, Hasanuddin University, Makassar 90245, Indonesia.
Department of Obstetrics and Gynecology, Hasanuddin University, Makassar 90245, Indonesia.
Cancers (Basel). 2021 Mar 9;13(5):1168. doi: 10.3390/cancers13051168.
Cervical cancer is the fourth leading cause of cancer-related death among women worldwide. The chemotherapeutical agent cisplatin, a small platinum-based compound, is considered as the standard therapy for locally advanced cervical cancer or recurrent cancers, sometimes in combination with radiotherapy or other drugs. However, drug resistance and radio-resistance phenomena could reduce the life expectancy of cervical cancer patients. Resistance mechanisms are complex and often involve multiple cellular pathways in which microRNAs (miRNAs) play a fundamental role. miRNAs are a class of endogenous non-coding small RNAs responsible for post-transcriptional gene regulation. Convincing evidence demonstrates that several deregulated miRNAs are important regulators in the onset of drug and radioresistance in cervical cancer, thus underlying their potential applications in a clinical setting. In this review, we summarized the mechanisms by which miRNAs affect both cisplatin and radioresistance in cervical cancer. We also described the regulatory loops between miRNAs and lncRNAs promoting drug resistance. Besides, we reported evidence for the role of miRNAs in sensitizing cancer cells to cisplatin-based chemotherapy, and provided some suggestions for the development of new combined therapies for cervical cancer.
宫颈癌是全球女性癌症相关死亡的第四大主要原因。化疗药物顺铂，一种小型铂基化合物，被视为局部晚期宫颈癌或复发性癌症的标准疗法，有时会与放疗或其他药物联合使用。然而，耐药性和放射抗性现象会缩短宫颈癌患者的预期寿命。耐药机制复杂，通常涉及多个细胞途径，其中微小RNA（miRNA）发挥着重要作用。miRNA是一类负责转录后基因调控的内源性非编码小RNA。有确凿证据表明，几种失调的miRNA是宫颈癌发生耐药和放射抗性的重要调节因子，因此也凸显了它们在临床环境中的潜在应用价值。在本综述中，我们总结了miRNA影响宫颈癌顺铂耐药和放射抗性的机制。我们还描述了miRNA与长链非编码RNA（lncRNA）之间促进耐药的调控环路。此外，我们报告了miRNA使癌细胞对基于顺铂的化疗敏感的作用证据，并为开发宫颈癌新的联合疗法提供了一些建议。
