Nordberg A, Adem A, Hardy J, Winblad B
Department of Pharmacology, University of Uppsala, Sweden.
Neurosci Lett. 1988 Apr 12;86(3):317-21. doi: 10.1016/0304-3940(88)90503-4.
Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.
使用（-）-[³H]尼古丁和未标记尼古丁进行的竞争实验表明，在对照组和阿尔茨海默病（AD/SDAT）患者大脑的颞叶皮质中存在高亲和力和低亲和力的烟碱结合位点。与对照大脑相比，AD/SDAT大脑皮质中高亲和力烟碱结合位点的比例显著降低（-20%），同时低亲和力烟碱结合位点的比例相应增加。此外，观察到AD/SDAT中低亲和力烟碱结合位点的亲和力显著下降。
