KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Korea.
Electronic Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul 02791, Korea.
Sensors (Basel). 2021 Mar 9;21(5):1922. doi: 10.3390/s21051922.
The breath gas analysis through gas phase chemical analysis draws attention in terms of non-invasive and real time monitoring. The array-type sensors are one of the diagnostic methods with high sensitivity and selectivity towards the target gases. Herein, we presented a 2 × 4 sensor array with a micro-heater and ceramic chip. The device is designed in a small size for portability, including the internal eight-channel sensor array. InO NRs and WO NRs manufactured through the E-beam evaporator's glancing angle method were used as sensing materials. Pt, Pd, and Au metal catalysts were decorated for each channel to enhance functionality. The sensor array was measured for the exhaled gas biomarkers CHCOCH, NO, and HS to confirm the respiratory diagnostic performance. Through this operation, the theoretical detection limit was calculated as 1.48 ppb for CHCOCH, 1.9 ppt for NO, and 2.47 ppb for HS. This excellent detection performance indicates that our sensor array detected the CHCOCH, NO, and HS as biomarkers, applying to the breath gas analysis. Our results showed the high potential of the gas sensor array as a non-invasive diagnostic tool that enables real-time monitoring.
通过气相化学分析进行呼气气体分析引起了人们的关注，因为这种方法具有非侵入性和实时监测的特点。阵列式传感器是一种具有高灵敏度和选择性的诊断方法，针对目标气体。在此，我们展示了一个带有微加热器和陶瓷芯片的 2×4 传感器阵列。该设备设计为小型便携式设备，包括内部的 8 通道传感器阵列。通过电子束蒸发器的掠角方法制造的 InO NRs 和 WO NRs 被用作传感材料。为每个通道都装饰了 Pt、Pd 和 Au 金属催化剂，以增强功能。该传感器阵列用于测量呼气生物标志物 CHCOCH、NO 和 HS，以确认呼吸诊断性能。通过这种操作，CHCOCH 的理论检测限计算为 1.48 ppb，NO 的理论检测限为 1.9 ppt，HS 的理论检测限为 2.47 ppb。这种出色的检测性能表明，我们的传感器阵列能够作为一种非侵入性诊断工具，实时监测 CHCOCH、NO 和 HS 等生物标志物。我们的结果表明，气体传感器阵列作为一种非侵入性诊断工具具有很大的潜力，可以实现实时监测。
