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修饰与封装：用于对抗病毒感染的病毒样颗粒

Decorated and Encapsulated: Virus-Like Particles Against Viral Infections.

作者信息

Temchura Vladimir

机构信息

Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany.

出版信息

Vaccines (Basel). 2021 Mar 18;9(3):273. doi: 10.3390/vaccines9030273.

DOI:10.3390/vaccines9030273
PMID:33803636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8002974/
Abstract

Despite great progress in the field of vaccine development, outbreaks of emerging pathogens and insufficient immunogenicity of some licensed vaccines call for the development of novel technologies in rational vaccine design [...].

摘要

尽管疫苗研发领域取得了巨大进展，但新出现病原体的爆发以及一些已获许可疫苗免疫原性不足，都需要在合理的疫苗设计中开发新技术[……]。

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本文引用的文献

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Immunogenicity of HIV-1-Based Virus-Like Particles with Increased Incorporation and Stability of Membrane-Bound Env.基于HIV-1的病毒样颗粒的免疫原性，其膜结合Env的掺入和稳定性增加。
Vaccines (Basel). 2021 Mar 10;9(3):239. doi: 10.3390/vaccines9030239.
2
The Use of Nanobiotechnology in Immunology and Vaccination.纳米生物技术在免疫学和疫苗接种中的应用。
Vaccines (Basel). 2021 Jan 21;9(2):74. doi: 10.3390/vaccines9020074.
3
Harnessing Cellular Immunity for Vaccination against Respiratory Viruses.利用细胞免疫进行呼吸道病毒疫苗接种
Vaccines (Basel). 2020 Dec 21;8(4):783. doi: 10.3390/vaccines8040783.
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Promotion of Cellular and Humoral Immunity against Foot-and-Mouth Disease Virus by Immunization with Virus-Like Particles Encapsulated in Monophosphoryl Lipid A and Liposomes.用单磷酰脂质A和脂质体包裹的病毒样颗粒免疫促进针对口蹄疫病毒的细胞免疫和体液免疫。
Vaccines (Basel). 2020 Oct 31;8(4):633. doi: 10.3390/vaccines8040633.
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SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates.SARS-CoV-2 免疫：综述及对 3 期疫苗候选物的应用。
Lancet. 2020 Nov 14;396(10262):1595-1606. doi: 10.1016/S0140-6736(20)32137-1. Epub 2020 Oct 13.
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A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice.使用嵌合昆虫特异性宾贾里病毒平台生成的寨卡疫苗可保护怀孕小鼠的胎儿脑部免受感染。
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