罕见呼吸系统疾病中的氧化应激与内质网应激
Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases.
作者信息
Magallón María, Pastor Sara, Carrión Ana Esther, Bañuls Lucía, Pellicer Daniel, Castillo Silvia, Bondía Sergio, Navarro-García María Mercedes, González Cruz, Dasí Francisco
机构信息
Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain.
Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain.
出版信息
J Clin Med. 2021 Mar 18;10(6):1268. doi: 10.3390/jcm10061268.
Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.
多项研究表明，一些罕见的呼吸系统疾病，如α-1抗胰蛋白酶缺乏症（AATD）、特发性肺纤维化（IPF）、囊性纤维化（CF）和原发性纤毛运动障碍（PCD），均存在氧化应激（OS）和内质网（ER）应激。本综述讨论了它们在这些病理过程中的作用，以及使用抗氧化剂作为治疗药物以减轻OS影响的情况。
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