Chen Alice C-H, Burr Lucy, McGuckin Michael A
Diamantina Institute Faculty of Medicine The University of Queensland Brisbane QLD Australia.
Department of Cell and Molecular Therapy Royal Prince Alfred Hospital Sydney NSW Australia.
Clin Transl Immunology. 2018 Jun 13;7(6):e1019. doi: 10.1002/cti2.1019. eCollection 2018.
Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.
氧化应激和内质网（ER）应激是相关状态，可作为正常生理的一部分在细胞中发生，但在涉及炎症的疾病中经常出现。在本文中，我们综述了有关氧化应激和内质网应激在肺部急慢性非恶性疾病（包括感染、囊性纤维化、特发性肺纤维化和哮喘）病理生理学中的作用的最新研究结果。我们还探讨了靶向氧化应激和内质网应激途径的药物缓解疾病的潜力。
