Left Ventricle Architecture and Valvular Integrity Following Microaxial Mechanical Support: A Two-Year Follow-Up Study.

Although the use of microaxilar mechanical circulatory support systems may improve the outcome of patients with cardiogenic shock (CS), little is known about its effect on the long-term structural integrity of left ventricular (LV) valves as well as on the development of LV-architecture. Therefore, we aimed to study the integrity of the LV valves and architecture and function after Impella support. Thus, 84 consecutive patients were monitored over two years having received Impella CP ( = 24) or 2.5 ( = 60) for refractory CS ( = 62) or for high-risk percutaneous coronary interventions ( = 22) followed by optimal medical treatment. Beside a significant increase in LV ejection fraction after two years ( ≤ 0.03 vs. pre-implantation), we observed a statistically significant decrease in LV dilation ( < 0.001) and severity of mitral valve regurgitation ( = 0.007) in the two-year follow-up period, suggesting an improved LV architecture. Neither the duration of support, nor the size of the Impella device or the indication for its use revealed any devastating impact on aortic or mitral valve integrity. These findings indicate that Impella device is a safe means of support of LV-function without detrimental long-term effects on the structural integrity of LV valves regardless of the size of the device or the indication of support.