Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 81362, Taiwan.
Institute of BioPharmaceutical Sciencesciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan.
Sci Rep. 2021 Mar 18;11(1):6336. doi: 10.1038/s41598-021-85915-x.
Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1935 infertile women aged 20-46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.
抗缪勒管激素（AMH）和睾酮（T）在卵泡发生的早期阶段都发挥着独特的作用。然而，血清 T 和 AMH 水平之间的关系尚未得到充分理解。本研究旨在探讨不孕妇女血清 T 和 AMH 水平之间的关系。本横断面研究共纳入 1935 名 20-46 岁的不孕妇女，根据血清 T 水平分为四个四分位组（Q1 至 Q4）。与 T 最高四分位组（Q4）的受试者相比，T 最低四分位组（Q1）的 AMH 水平显著降低。调整年龄、体重、体重指数和 FSH 后，T 四分位组的增加与 AMH 水平的升高相关。二元逻辑回归分析显示，Q1 组发生卵巢储备功能减退（DOR）的风险是 Q4 组的 11.44 倍，Q4 组发生卵巢储备过度（EOR）的风险是 Q1 组的 10.41 倍。我们的数据表明，血清 T 水平与血清 AMH 水平呈正相关，并提示雄激素不足可能是 DOR 的潜在危险因素；雄激素过多可能导致不孕妇女发生 EOR。
