Demey Baptiste, Brault Clément, Maizel Julien, Francois Catherine
Department of Virology, Amiens University Medical Center, 80000 Amiens, France.
AGIR Research Unit, EA 4294, Jules Verne University of Picardie, 80000 Amiens, France.
Pathogens. 2021 Mar 15;10(3):340. doi: 10.3390/pathogens10030340.
Human adenovirus infection is rare in adult population, except for in immunocompromised individuals. Recipients of allogenic haploidentical hematopoietic stem cell transplantation are reported at high risk for human adenovirus, which is often lethal when it evolves into the disseminated form. Despite existent guidelines, prevention, early diagnosis, and therapeutics remain challenging. Here, we report the case of a fatal evolution of human adenovirus respiratory infection and discuss the actual recommendations to prevent recurrence of this major issue.
人类腺病毒感染在成年人群中较为罕见，免疫功能低下者除外。据报道，接受单倍体相合异基因造血干细胞移植的患者感染人类腺病毒的风险很高，当感染发展为播散型时往往会致命。尽管有现行指南，但预防、早期诊断和治疗仍然具有挑战性。在此，我们报告一例人类腺病毒呼吸道感染致死的病例，并讨论预防这一重大问题复发的实际建议。
