Takamatsu Akane, Tagashira Yasuaki, Hasegawa Shinya, Honda Hitoshi
Division of Infectious Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
Future Sci OA. 2019 Aug 28;5(8):FSO412. doi: 10.2144/fsoa-2019-0072.
Human adenoviruses cause a wide spectrum of illnesses, including invasive infections, in immunocompromised hosts. We report a case of disseminated adenovirus infection following unrelated cord-blood transplantation in a 46-year-old male with a lymphoma. A review of the literature on disseminated adenovirus infections in adult patients with hematopoietic stem cell transplantation has also been included. Despite antiviral therapy, the mortality rate in hematopoietic stem cell transplantation recipients with a disseminated adenovirus infection is as high as 72%, and estimating the risk of human adenovirus infection in a timely manner is crucial to improving outcomes.
人类腺病毒可引起广泛的疾病，包括免疫功能低下宿主中的侵袭性感染。我们报告了一例46岁淋巴瘤男性在接受无关脐血移植后发生播散性腺病毒感染的病例。本文还纳入了对成年造血干细胞移植患者播散性腺病毒感染相关文献的综述。尽管进行了抗病毒治疗，但造血干细胞移植受者发生播散性腺病毒感染的死亡率高达72%，及时评估人类腺病毒感染风险对于改善预后至关重要。
