Marketou Maria, Kontaraki Joanna, Patrianakos Alexandros, Kochiadakis George, Anastasiou Ioannis, Fragkiadakis Konstantinos, Plevritaki Anthoula, Papadaki Sofia Thalia, Chlouverakis Gregory, Parthenakis Fragiskos
Cardiology Department, University General Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Department of Molecular Cardiology, School of Medicine, University of Crete, 71110 Heraklion, Crete, Greece.
Genes (Basel). 2021 Mar 15;12(3):420. doi: 10.3390/genes12030420.
microRNAs (miRs) have emerged as important modulators of cardiovascular development and disease. Our aim was to determine whether cardiac-related miRs such as miR-21-5p and miR-1-3p were differentially expressed in acute viral myocarditis and whether any of them was related with the extent of myocardial damage and left ventricular dysfunction.
We enrolled 40 patients with acute viral myocarditis. Blood samples were taken on admission and miRs expression levels in peripheral blood mononuclear cells were quantified by real-time reverse transcription polymerase chain reaction.
miR-21-5p, miR-1-3p were significantly elevated in acute myocarditis. miR-21-5p levels showed a strong correlation with global longitudinal strain ( = 0.71, < 0.01), while miR-1-3p had significant correlations with troponin I ( = 0.79, < 0.01).
The expression of miR-21-5p and miR-1-3p in peripheral blood is increased in acute viral myocarditis, and this increase is correlated with myocardial damage and indicative of left ventricular systolic dysfunction in these patients.
微小RNA（miRs）已成为心血管发育和疾病的重要调节因子。我们的目的是确定心脏相关的miRs，如miR-21-5p和miR-1-3p在急性病毒性心肌炎中是否差异表达，以及它们是否与心肌损伤程度和左心室功能障碍有关。
我们纳入了40例急性病毒性心肌炎患者。入院时采集血样，通过实时逆转录聚合酶链反应定量外周血单个核细胞中的miRs表达水平。
miR-21-5p、miR-1-3p在急性心肌炎中显著升高。miR-21-5p水平与整体纵向应变呈强相关（r = 0.71，P < 0.01），而miR-1-3p与肌钙蛋白I显著相关（r = 0.79，P < 0.01）。
急性病毒性心肌炎患者外周血中miR-21-5p和miR-1-3p的表达增加，这种增加与心肌损伤相关，并提示这些患者存在左心室收缩功能障碍。
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