Annexin A1 Expression Is Associated with Epithelial-Mesenchymal Transition (EMT), Cell Proliferation, Prognosis, and Drug Response in Pancreatic Cancer.

Annexin A1 () is a calcium-dependent phospholipid-binding protein overexpressed in pancreatic cancer (PC). expression has been shown to take part in a wide variety of cancer biology, including carcinogenesis, cell proliferation, invasion, apoptosis, and metastasis, in addition to the initially identified anti-inflammatory effect in experimental settings. We hypothesized that expression is associated with cell proliferation and survival in PC patients. To test this hypothesis, we analyzed 239 PC patients in The Cancer Genome Atlas (TCGA) and GSE57495 cohorts. expression correlated with epithelial-mesenchymal transition (EMT) but weakly with angiogenesis in PC patients. -high PC was significantly associated with a high fraction of fibroblasts and keratinocytes in the tumor microenvironment. high PC enriched multiple malignant gene sets, including hypoxia, tumor necrosis factor (TNF)-α signaling via nuclear factor-kappa B (NF-kB), and MTORC1, as well as apoptosis, protein secretion, glycolysis, and the androgen response gene sets consistently in both cohorts. expression was associated with TP53 mutation alone but associated with all KRAS, p53, E2F, and transforming growth factor (TGF)-β signaling pathways and also associated with homologous recombination deficiency in the TCGA cohort. high PC was associated with a high infiltration of T-helper type 2 cells in the TME, with advanced histological grade and expression, as well as with a worse prognosis regardless of the grade. expression correlated with a sensitivity to gemcitabine, doxorubicin, and 5-fluorouracil in PC cell lines. In conclusion, expression is associated with EMT, cell proliferation, survival, and the drug response in PC.