Henry Patricia, Halbus Ahmed F, Athab Zahraa H, Paunov Vesselin N
Department of Chemistry and Biochemistry, University of Hull, Hull HU67RX, UK.
Department of Chemistry, College of Science, University of Babylon, Hilla 51001, Iraq.
Biomimetics (Basel). 2021 Mar 15;6(1):19. doi: 10.3390/biomimetics6010019.
Antimould agents are widely used in different applications, such as specialty paints, building materials, wood preservation and crop protection. However, many antimould agents can be toxic to the environment. This work aims to evaluate the application of copper oxide nanoparticles (CuONPs) surface modified with boronic acid (BA) terminal groups as antimould agents. We developed CuONPs grafted with (3-glycidyloxypropyl) trimethoxysilane (GLYMO), coupled with 4-hydroxyphenylboronic acid (4-HPBA), which provided a strong boost of their action as antimould agents. We studied the antimould action of the 4-HPBA-functionalized CuONPs against two mould species: () and (). The cis-diol groups of polysaccharides expressed on the mould cell walls can form reversible covalent bonds with the BA groups attached on the CuONPs surface. This allowed them to bind strongly to the mould surface, resulting in a very substantial boost of their antimould activity, which is not based on electrostatic adhesion, as in the case of bare CuONPs. The impact of these BA-surface functionalized nanoparticles was studied by measuring the growth of the mould colonies versus time. The BA-functionalized CuONPs showed significant antimould action, compared to the untreated mould sample at the same conditions and period of time. These results can be applied for the development of more efficient antimould treatments at a lower concentration of active agent with potentially substantial economic and environmental benefits.
防霉剂广泛应用于不同领域，如特种涂料、建筑材料、木材防腐和作物保护。然而，许多防霉剂可能对环境有毒。这项工作旨在评估用硼酸（BA）端基表面改性的氧化铜纳米颗粒（CuONPs）作为防霉剂的应用。我们开发了接枝有（3-缩水甘油氧基丙基）三甲氧基硅烷（GLYMO）并与4-羟基苯硼酸（4-HPBA）偶联的CuONPs，这极大地增强了它们作为防霉剂的作用。我们研究了4-HPBA功能化的CuONPs对两种霉菌的防霉作用：（）和（）。霉菌细胞壁上表达的多糖的顺式二醇基团可与附着在CuONPs表面的BA基团形成可逆共价键。这使它们能够牢固地结合在霉菌表面，从而极大地增强了它们的防霉活性，这与裸CuONPs的情况不同，裸CuONPs的防霉活性不是基于静电粘附。通过测量霉菌菌落的生长随时间的变化来研究这些BA表面功能化纳米颗粒的影响。与相同条件和时间段内未处理的霉菌样品相比，BA功能化的CuONPs显示出显著的防霉作用。这些结果可用于开发在较低活性剂浓度下更有效的防霉处理方法，具有潜在的重大经济和环境效益。
