Aguilar-Palacio Isabel, Malo Sara, Jarauta Estibaliz, Moreno-Franco Belén, Maldonado Lina, Compés Luisa, Rabanaque Mª José, Casasnovas José Antonio
Preventive Medicine and Public Health Department, University of Zaragoza, 50009 Zaragoza, Spain.
Instituto Aragonés de Ciencias de Salud, IIS Aragón, 50009 Zaragoza, Spain.
J Clin Med. 2021 Mar 1;10(5):945. doi: 10.3390/jcm10050945.
The objective of this study is to describe the profile of primary preventive treatment for cardiovascular disease in adult males and to analyze the association between treatment profile and subclinical atherosclerosis. We selected male workers who had undergone ultrasound imaging and had no previous history of cardiovascular disease ( = 2138). Data on the consumption of primary cardiovascular drugs from the previous year were obtained. We performed bivariate analyses to compare patient characteristics according to cardiovascular treatment and the presence of subclinical atherosclerosis, and logistic regression models to explore the association between these two variables. Among participants with no personal history of cardiovascular disease, subclinical atherosclerosis was present in 77.7% and 31.2% had received some form of preventive treatment. Of those who received no preventive treatment, 73.6% had subclinical atherosclerosis. Cardiovascular preventive treatment was associated only with CACS > 0 (odds ratio (OR), 1.37; 95% confidence interval (95% CI), 1.06-1.78). Statin treatment was associated with a greater risk of any type of subclinical atherosclerosis (OR, 1.73) and with CACS > 0 (OR, 1.72). Subclinical atherosclerosis existed in almost 75% of men who had no personal history of cardiovascular disease and had not received preventive treatment for cardiovascular disease.
本研究的目的是描述成年男性心血管疾病一级预防治疗的概况，并分析治疗概况与亚临床动脉粥样硬化之间的关联。我们选取了接受过超声成像检查且既往无心血管疾病史的男性工人（=2138人）。获取了他们上一年心血管主要药物的使用数据。我们进行了双变量分析，以比较根据心血管治疗情况和亚临床动脉粥样硬化情况的患者特征，并进行逻辑回归模型分析以探索这两个变量之间的关联。在无心血管疾病个人史的参与者中，77.7%存在亚临床动脉粥样硬化，31.2%接受过某种形式的预防治疗。在未接受预防治疗的人群中，73.6%存在亚临床动脉粥样硬化。心血管预防治疗仅与冠状动脉钙化积分（CACS）>0相关（比值比（OR），1.37；95%置信区间（95%CI），1.06 - 1.78）。他汀类药物治疗与任何类型的亚临床动脉粥样硬化风险增加相关（OR，1.73），与CACS>0相关（OR，1.72）。在无心血管疾病个人史且未接受心血管疾病预防治疗的男性中，近75%存在亚临床动脉粥样硬化。
